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Catalog Number:
48172
CAS Number:
2002499-17-2
Fmoc-D-His(3-Me)-OH
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-3-methyl-D-histidine, Fmoc-D-His(p-Me)-OH
Documents
$50.00 /25MG
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Product Information

Fmoc-D-His(3-Me)-OH is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during solid-phase peptide synthesis. Its unique structure, incorporating a 3-methylimidazole side chain, enhances its compatibility with various coupling reagents, making it an ideal choice for researchers focused on synthesizing complex peptides and proteins.

In addition to its role in peptide synthesis, Fmoc-D-His(3-Me)-OH is also valuable in the development of pharmaceuticals and bioconjugates, where its imidazole functionality can participate in metal coordination and enzyme catalysis. This compound's stability and ease of handling further contribute to its appeal in laboratory settings, allowing for efficient synthesis processes. Researchers and industry professionals can leverage Fmoc-D-His(3-Me)-OH to create innovative solutions in drug discovery and development, making it a crucial tool in modern biochemical research.

Synonyms
Fmoc-3-methyl-D-histidine, Fmoc-D-His(p-Me)-OH
CAS Number
2002499-17-2
Purity
≥ 98% (HPLC)
Molecular Formula
C22H21N3O4
Molecular Weight
391.42
MDL Number
MFCD30187627
Melting Point
165 - 168 °C
Appearance
White powder
Optical Rotation
[a]D20 = 5.2 ± 3 °C (C=1 in 1N HCl)
Conditions
Store at RT
General Information
Synonyms
Fmoc-3-methyl-D-histidine, Fmoc-D-His(p-Me)-OH
CAS Number
2002499-17-2
Purity
≥ 98% (HPLC)
Molecular Formula
C22H21N3O4
Molecular Weight
391.42
MDL Number
MFCD30187627
Melting Point
165 - 168 °C
Appearance
White powder
Optical Rotation
[a]D20 = 5.2 ± 3 °C (C=1 in 1N HCl)
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-D-His(3-Me)-OH is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in the synthesis of peptides, allowing for the selective modification of amino acids. Its stability under various conditions makes it a preferred choice for researchers in biochemistry.
  • Drug Development: Its unique structure aids in the design of novel pharmaceuticals, particularly in targeting specific biological pathways. This can enhance the efficacy of drug candidates in the pharmaceutical industry.
  • Bioconjugation: The compound is used in bioconjugation processes, where it helps attach biomolecules to surfaces or other molecules, facilitating the development of biosensors and targeted drug delivery systems.
  • Research in Cancer Therapy: Its application in the synthesis of histidine-containing peptides is significant in cancer research, where these peptides can be used to develop targeted therapies that improve treatment outcomes.
  • Protein Engineering: Fmoc-D-His(3-Me)-OH is instrumental in protein engineering, allowing scientists to create modified proteins with enhanced properties for various applications, including enzyme design and therapeutic proteins.

Citations