Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
48171
CAS Number:
1197025-85-6
Na-Fmoc-Nim-methyl-D-histidine
Purity:
≥ 95% (HPLC)
Synonym(s):
Fmoc-D-His(1-Me)-OH
Documents
$80.00 /25MG
Pack Size Availability Price
Request Bulk Quote
Product Information

Na-Fmoc-Nim-methyl-D-histidine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which facilitates the selective modification of amino acids during solid-phase peptide synthesis. Its unique structure, characterized by the incorporation of a methylated imidazole side chain, enhances the stability and bioactivity of peptides, making it an essential building block for researchers in medicinal chemistry and biochemistry.

In practical applications, Na-Fmoc-Nim-methyl-D-histidine is particularly valuable in the design of peptide-based therapeutics and in the study of protein interactions. Its ability to mimic natural histidine residues allows for the exploration of enzyme mechanisms and the development of inhibitors. Furthermore, the compound's favorable solubility and compatibility with various coupling reagents make it an ideal choice for researchers aiming to synthesize complex peptides efficiently. With its robust profile, Na-Fmoc-Nim-methyl-D-histidine stands out as a crucial tool for advancing peptide research and development.

Synonyms
Fmoc-D-His(1-Me)-OH
CAS Number
1197025-85-6
Purity
≥ 95% (HPLC)
Molecular Formula
C22H21N3O4
Molecular Weight
391.42
MDL Number
MFCD30748650
Melting Point
135 - 167 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = 9.1 ± 5 ° (C=1 in 2N HCl)
Conditions
Store at RT
General Information
Synonyms
Fmoc-D-His(1-Me)-OH
CAS Number
1197025-85-6
Purity
≥ 95% (HPLC)
Molecular Formula
C22H21N3O4
Molecular Weight
391.42
MDL Number
MFCD30748650
Melting Point
135 - 167 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = 9.1 ± 5 ° (C=1 in 2N HCl)
Conditions
Store at RT
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nim-methyl-D-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, especially in the production of modified peptides that can enhance biological activity.
  • Drug Development: It is used in the development of pharmaceuticals, particularly in creating compounds that target specific biological pathways, offering potential advantages in efficacy and specificity.
  • Bioconjugation: The chemical is employed in bioconjugation processes, allowing researchers to attach biomolecules to surfaces or other molecules, which is crucial in diagnostics and therapeutic applications.
  • Protein Engineering: It plays a significant role in protein engineering, where modifications can lead to improved stability and functionality of proteins, benefiting various biotechnological applications.
  • Research in Neuroscience: The compound is relevant in neuroscience research, particularly in studying receptor interactions and signaling pathways, which can lead to advancements in understanding neurological disorders.

Citations