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Catalog Number:
48072
CAS Number:
40733-27-5
3'-O-[tert-Butyl(dimethyl)silyl]thymidine
Purity:
≥ 98% (HPLC)
Synonym(s):
3'-O-(TBDMS)Thymidine
Documents
$143.00 /250MG
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Product Information

3'-O-[tert-Butyl(dimethyl)silyl]thymidine is a versatile chemical compound that plays a significant role in the field of nucleoside chemistry and biochemistry. This modified thymidine derivative is particularly useful in the synthesis of oligonucleotides, where it serves as a protective group that enhances the stability and solubility of nucleic acids during chemical reactions. Its unique tert-butyl(dimethyl)silyl group provides robust protection against unwanted reactions, making it an essential reagent in the development of therapeutic nucleic acids and in various research applications.

In addition to its protective capabilities, 3'-O-[tert-Butyl(dimethyl)silyl]thymidine is also employed in the study of DNA and RNA interactions, facilitating the exploration of nucleic acid structures and functions. Researchers appreciate its ability to improve the efficiency of synthesis processes while minimizing side reactions, which is crucial for producing high-quality nucleic acid products. This compound is ideal for laboratories focused on genetic research, drug development, and molecular biology, offering a reliable solution for enhancing nucleic acid manipulation.

Synonyms
3'-O-(TBDMS)Thymidine
CAS Number
40733-27-5
Purity
≥ 98% (HPLC)
Molecular Formula
C16H28N2O5Si
Molecular Weight
356.49
MDL Number
MFCD01631040
Appearance
White to light yellow powder
Optical Rotation
[a]D20 = 26 - 30 ° (C=1 in chloroform)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
3'-O-(TBDMS)Thymidine
CAS Number
40733-27-5
Purity
≥ 98% (HPLC)
Molecular Formula
C16H28N2O5Si
Molecular Weight
356.49
MDL Number
MFCD01631040
Appearance
White to light yellow powder
Optical Rotation
[a]D20 = 26 - 30 ° (C=1 in chloroform)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

3'-O-[tert-Butyl(dimethyl)silyl]thymidine is widely utilized in research focused on:

  • Nucleoside Synthesis: This compound serves as a key intermediate in the synthesis of modified nucleosides, which are crucial for developing antiviral and anticancer therapies.
  • Drug Development: It is used in the creation of prodrugs that enhance the bioavailability of nucleoside analogs, improving their therapeutic efficacy in clinical applications.
  • Biochemical Research: Researchers employ this compound to study DNA and RNA interactions, aiding in the understanding of genetic processes and the development of gene therapies.
  • Analytical Chemistry: It is utilized as a standard in chromatographic techniques, helping to quantify nucleoside derivatives in complex biological samples.
  • Material Science: The compound is explored in the development of novel materials for drug delivery systems, enhancing the targeted delivery of therapeutic agents.

Citations