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Catalog Number:
48034
CAS Number:
13860-38-3
1-Methylpseudouridine
Purity:
≥ 99% (HPLC)
Synonym(s):
1-Methyl-5-β-D-ribofuranosyluracil, 1-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H-pyrimidinedione
Documents
$255.20 /100MG
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Product Information

1-Methylpseudouridine is a modified nucleoside that plays a significant role in various biological and pharmaceutical applications. This compound is recognized for its ability to enhance the stability and efficacy of RNA molecules, making it a valuable tool in the development of RNA-based therapeutics and vaccines. Researchers utilize 1-Methylpseudouridine to improve the performance of mRNA in therapeutic applications, particularly in the context of mRNA vaccines, where it helps to reduce immunogenicity while maintaining protein expression levels.

Additionally, 1-Methylpseudouridine is employed in the synthesis of oligonucleotides, where its incorporation can lead to improved resistance to nucleases and enhanced cellular uptake. This property is particularly beneficial in gene therapy and antisense oligonucleotide applications, where stability and delivery are critical. The unique characteristics of 1-Methylpseudouridine make it an essential compound for researchers and industry professionals focused on advancing RNA technology and therapeutic development.

Synonyms
1-Methyl-5-β-D-ribofuranosyluracil, 1-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H-pyrimidinedione
CAS Number
13860-38-3
Purity
≥ 99% (HPLC)
Molecular Formula
C10H14N2O6
Molecular Weight
258.23
MDL Number
MFCD10687017
Melting Point
187 - 191 °C
Appearance
White to light yellow powder
Optical Rotation
[a]D20 = -8 to -6 ° (C=1 in water)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
1-Methyl-5-β-D-ribofuranosyluracil, 1-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H-pyrimidinedione
CAS Number
13860-38-3
Purity
≥ 99% (HPLC)
Molecular Formula
C10H14N2O6
Molecular Weight
258.23
MDL Number
MFCD10687017
Melting Point
187 - 191 °C
Appearance
White to light yellow powder
Optical Rotation
[a]D20 = -8 to -6 ° (C=1 in water)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

1-Methylpseudouridine is widely utilized in research focused on:

  • RNA Therapeutics: It is incorporated into RNA molecules to enhance their stability and reduce immunogenicity, making it valuable in the development of mRNA vaccines and therapeutics.
  • Gene Expression Studies: Researchers use it to modify RNA transcripts, allowing for better understanding of gene regulation and expression mechanisms.
  • Antiviral Research: Its application in designing antiviral agents is significant, as it can help in the development of RNA-based therapies against viral infections.
  • Biotechnology: In the production of recombinant proteins, it aids in optimizing mRNA for improved translation efficiency, which is crucial for biopharmaceutical manufacturing.
  • Diagnostics: It is used in the design of diagnostic assays, enhancing the sensitivity and specificity of RNA detection methods in various diseases.

Citations