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Catalog Number:
47394
CAS Number:
460751-66-0
Fmoc-5-bromo-L-tryptophan
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-L-Trp(5-Br)-OH, Fmoc-Trp(5-Br)-OH
Documents
$70.00 /250MG
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Product Information

Fmoc-5-bromo-L-tryptophan is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which facilitates the selective coupling of amino acids during solid-phase peptide synthesis. Its unique 5-bromo substitution enhances its reactivity and allows for the introduction of bromine into peptide sequences, making it an invaluable tool for researchers aiming to create novel peptides with specific biological activities.

In the pharmaceutical industry, Fmoc-5-bromo-L-tryptophan is particularly relevant for the development of peptide-based therapeutics, including those targeting neurological disorders and cancer. Its ability to incorporate halogenated amino acids into peptides can lead to improved binding affinities and enhanced pharmacological properties. Researchers appreciate its stability and ease of use, which streamline the synthesis process while ensuring high purity and yield. This compound stands out for its potential to create complex peptide structures that can be tailored for specific applications in drug discovery and development.

Synonyms
Fmoc-L-Trp(5-Br)-OH, Fmoc-Trp(5-Br)-OH
CAS Number
460751-66-0
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C26H21BrN2O4
Molecular Weight
505.4
MDL Number
MFCD28166519
PubChem ID
24902264
Melting Point
190 - 200 °C (Lit.)
Appearance
White solid
Conditions
Store at 4 °C
General Information
Synonyms
Fmoc-L-Trp(5-Br)-OH, Fmoc-Trp(5-Br)-OH
CAS Number
460751-66-0
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C26H21BrN2O4
Molecular Weight
505.4
MDL Number
MFCD28166519
PubChem ID
24902264
Melting Point
190 - 200 °C (Lit.)
Appearance
White solid
Conditions
Store at 4 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-5-bromo-L-tryptophan is widely utilized in research focused on:

  • Peptide Synthesis: This compound is an essential building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing researchers to create complex peptides with specific sequences.
  • Drug Development: Its unique structure makes it valuable in medicinal chemistry for developing new pharmaceuticals, especially those targeting neurological disorders, due to the tryptophan moiety's role in serotonin production.
  • Bioconjugation: The bromo group allows for selective reactions, making it useful in bioconjugation techniques to attach biomolecules to surfaces or other molecules, enhancing drug delivery systems.
  • Fluorescent Probes: The Fmoc group can be utilized in creating fluorescent probes for biological imaging, providing insights into cellular processes and molecular interactions.
  • Research in Neuroscience: Its application in studying neurotransmitter pathways helps researchers understand mood regulation and the biochemical basis of depression and anxiety.

Citations