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Catalog Number:
46596
CAS Number:
40949-94-8
Potassium bis(trimethylsilyl)amide solution, 0.5 M in toluene
Purity:
0.47 - 0.58 M (Assay by titration)
Synonym(s):
Hexamethyldisilazane potassium salt solution, Potassium hexamethyldisilazide solution
Hazmat
Documents
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Product Information

Potassium bis(trimethylsilyl)amide solution, 0.5 M in toluene, is a versatile reagent widely utilized in organic synthesis and materials science. This compound serves as a potent base and nucleophile, making it ideal for deprotonation reactions and the synthesis of various organosilicon compounds. Its unique structure allows for enhanced reactivity, particularly in the formation of carbon-nitrogen bonds, which is crucial in the development of pharmaceuticals and agrochemicals. Researchers appreciate its stability in toluene, providing a reliable medium for reactions that require an inert atmosphere.

In addition to its applications in organic synthesis, this potassium bis(trimethylsilyl)amide solution is also employed in the preparation of lithium and sodium amides, facilitating the production of advanced materials such as polymers and nanocomposites. Its ability to act as a strong base allows for the activation of various substrates, leading to efficient and selective reactions. This compound stands out for its ease of handling and compatibility with a range of organic solvents, making it a preferred choice for both academic and industrial laboratories.

Synonyms
Hexamethyldisilazane potassium salt solution, Potassium hexamethyldisilazide solution
CAS Number
40949-94-8
Purity
0.47 - 0.58 M (Assay by titration)
Molecular Formula
C6H18KNSi2
Molecular Weight
0
MDL Number
MFCD00010330
PubChem ID
3251421
Density
0.877 g/mL at 25 °C
Appearance
Colorless to yellow liquid
Conditions
Store at RT
General Information
Synonyms
Hexamethyldisilazane potassium salt solution, Potassium hexamethyldisilazide solution
CAS Number
40949-94-8
Purity
0.47 - 0.58 M (Assay by titration)
Molecular Formula
C6H18KNSi2
Molecular Weight
0
MDL Number
MFCD00010330
PubChem ID
3251421
Density
0.877 g/mL at 25 °C
Appearance
Colorless to yellow liquid
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Potassium bis(trimethylsilyl)amide solution, 0.5 M in toluene is widely utilized in research focused on:

  • Organic Synthesis: This chemical acts as a strong base and nucleophile, making it ideal for deprotonation reactions and the formation of carbon-carbon bonds in organic synthesis.
  • Metalation Reactions: It is commonly used in metalation processes, where it helps to introduce metal centers into organic molecules, facilitating the development of new materials and catalysts.
  • Polymer Chemistry: The compound serves as a key reagent in the synthesis of silicon-containing polymers, which are valued for their thermal stability and flexibility in various applications.
  • Research in Catalysis: Researchers leverage its properties to create innovative catalytic systems that improve reaction efficiency and selectivity in chemical processes.
  • Pharmaceutical Development: It is utilized in the synthesis of pharmaceutical intermediates, aiding in the development of new drugs with enhanced efficacy and reduced side effects.

Citations