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Catalog Number:
46579
CAS Number:
1446752-61-9
Fmoc-Leu-(Dmb)Gly-OH
Purity:
≥ 98% (HPLC)
Synonym(s):
N-α-Fmoc-L-leucyl-N-α-(2,4-dimethoxybenzyl)-glycine
Documents
$110.70 /100MG
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Product Information

Fmoc-Leu-(Dmb)Gly-OH is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its unique structure, incorporating a 2,4-dimethoxyphenylmethyl group, enhances its stability and solubility, making it an excellent choice for researchers focused on complex peptide sequences.

In practical applications, Fmoc-Leu-(Dmb)Gly-OH is particularly valuable in the pharmaceutical industry for the development of peptide-based therapeutics. Its ability to facilitate the synthesis of modified peptides allows for the exploration of novel drug candidates with improved efficacy and reduced side effects. Additionally, this compound is instrumental in the production of peptide libraries for high-throughput screening, enabling researchers to identify potential leads in drug discovery. With its robust properties and significant utility, Fmoc-Leu-(Dmb)Gly-OH stands out as a critical tool for professionals in medicinal chemistry and biochemistry.

Synonyms
N-α-Fmoc-L-leucyl-N-α-(2,4-dimethoxybenzyl)-glycine
CAS Number
1446752-61-9
Purity
≥ 98% (HPLC)
Molecular Formula
C32H36N2O7
Molecular Weight
560.64
Appearance
White to off-white powder
Optical Rotation
[a]D25 = -30 to -25 ° (C=1 in MeOH) (Lit.)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
N-α-Fmoc-L-leucyl-N-α-(2,4-dimethoxybenzyl)-glycine
CAS Number
1446752-61-9
Purity
≥ 98% (HPLC)
Molecular Formula
C32H36N2O7
Molecular Weight
560.64
Appearance
White to off-white powder
Optical Rotation
[a]D25 = -30 to -25 ° (C=1 in MeOH) (Lit.)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-Leu-(Dmb)Gly-OH is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS). Its protective groups allow for selective reactions, making it easier to construct complex peptide sequences.
  • Drug Development: In pharmaceutical research, it is used to create peptide-based drugs. The ability to modify the structure can enhance the efficacy and stability of therapeutic peptides, which is crucial in developing new medications.
  • Bioconjugation: The compound is valuable in bioconjugation techniques, where it can be linked to other biomolecules. This application is particularly important in creating targeted drug delivery systems, improving the specificity and effectiveness of treatments.
  • Research in Molecular Biology: It is employed in studies involving protein interactions and functions. By incorporating this compound into proteins, researchers can investigate how modifications affect biological activity, aiding in the understanding of various cellular processes.
  • Development of Diagnostic Tools: The compound can be used in the design of biosensors and diagnostic assays. Its ability to form stable complexes with other molecules enhances the sensitivity and specificity of detection methods in clinical applications.

Citations