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Catalog Number:
42449
CAS Number:
21919-05-1
CB-1954
Purity:
≥ 98% (HPLC)
Synonym(s):
Tretazicar, 5-(Aziridin-1-yl)-2,4-dinitrobenzamide, 2,4-Dinitro-5-ethyleneiminobenzamide
Documents
$124.99 /10MG
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Product Information

CB-1954, also known as 5-(aziridin-1-yl)-2,4-dinitrobenzamide, is a potent compound recognized for its unique properties and applications in the field of cancer research. This small molecule has garnered attention for its ability to selectively target and inhibit the activity of certain DNA repair enzymes, making it a valuable tool in the development of targeted cancer therapies. Researchers have utilized CB-1954 in combination with other chemotherapeutic agents to enhance the efficacy of treatment regimens, particularly in tumors that exhibit resistance to conventional therapies. Its mechanism of action, which involves the formation of DNA cross-links, allows for the induction of apoptosis in cancer cells, thereby presenting a promising avenue for therapeutic intervention.

In addition to its applications in oncology, CB-1954 has potential uses in the study of gene therapy and the development of novel drug delivery systems. Its ability to penetrate cellular membranes and interact with nucleic acids positions it as a candidate for further exploration in the realm of molecular biology. The compound's unique profile not only aids in advancing cancer treatment strategies but also opens doors for innovative research methodologies, making it an essential addition to any laboratory focused on cutting-edge therapeutic developments.

Synonyms
Tretazicar, 5-(Aziridin-1-yl)-2,4-dinitrobenzamide, 2,4-Dinitro-5-ethyleneiminobenzamide
CAS Number
21919-05-1
Purity
≥ 98% (HPLC)
Molecular Formula
C9H8N4O5
Molecular Weight
252.19
MDL Number
MFCD00869490
PubChem ID
89105
Melting Point
173 - 177 °C
Appearance
White, yellow or orange crystalline powder
Conditions
Store at ≤ -10 °C
General Information
Synonyms
Tretazicar, 5-(Aziridin-1-yl)-2,4-dinitrobenzamide, 2,4-Dinitro-5-ethyleneiminobenzamide
CAS Number
21919-05-1
Purity
≥ 98% (HPLC)
Molecular Formula
C9H8N4O5
Molecular Weight
252.19
MDL Number
MFCD00869490
PubChem ID
89105
Melting Point
173 - 177 °C
Appearance
White, yellow or orange crystalline powder
Conditions
Store at ≤ -10 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

CB-1954 is widely utilized in research focused on:

  • Cancer Therapy: This compound is being investigated for its ability to selectively target and kill cancer cells, making it a promising candidate for developing new cancer treatments.
  • Gene Therapy: CB-1954 is used in gene therapy research, particularly in the context of creating targeted therapies that can modify gene expression in specific tissues.
  • Bioconjugation: In the field of biochemistry, it serves as a useful tool for bioconjugation, allowing researchers to attach drugs or imaging agents to biomolecules for enhanced therapeutic effects.
  • Drug Development: Pharmaceutical companies are exploring its potential as a lead compound in the development of new drugs, especially for diseases that are resistant to current treatments.
  • Research on Nitroreductases: CB-1954 is a valuable substrate in studies involving nitroreductases, enzymes that play a critical role in drug metabolism and activation, providing insights into drug efficacy and safety.

Citations