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Catalog Number:
42395
CAS Number:
18107-18-1
Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L)
Purity:
≥ 10% (NMR)
Synonym(s):
TMS-Diazomethane (ca. 10% in Hexane, ca. 0.6mol/L)
Hazmat
Documents
$134.70 /10ML
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Product Information

Trimethylsilyldiazomethane is a versatile reagent widely utilized in organic synthesis, particularly in the field of medicinal chemistry. This compound serves as an effective source of diazomethane, enabling the formation of various functional groups through its unique reactivity. Its ability to introduce methyl groups into target molecules makes it invaluable for researchers looking to modify complex organic structures. The presence of the trimethylsilyl group enhances its stability and solubility, allowing for easier handling and application in diverse solvent systems, such as hexane.

In practical applications, Trimethylsilyldiazomethane is commonly employed in the synthesis of nitrogen-containing compounds, including pharmaceuticals and agrochemicals. Its efficiency in generating diazo compounds facilitates the development of novel materials and intermediates, making it a preferred choice for chemists aiming to streamline their synthetic pathways. With its favorable properties and broad applicability, this compound stands out as a key reagent for advancing research and development in various chemical industries.

Synonyms
TMS-Diazomethane (ca. 10% in Hexane, ca. 0.6mol/L)
CAS Number
18107-18-1
Purity
≥ 10% (NMR)
Molecular Formula
C4H10N2Si
Molecular Weight
114.22
MDL Number
MFCD00053946
PubChem ID
167693
Appearance
Clear colorless liquid
Conditions
Store at 2 - 8 °C
General Information
Synonyms
TMS-Diazomethane (ca. 10% in Hexane, ca. 0.6mol/L)
CAS Number
18107-18-1
Purity
≥ 10% (NMR)
Molecular Formula
C4H10N2Si
Molecular Weight
114.22
MDL Number
MFCD00053946
PubChem ID
167693
Appearance
Clear colorless liquid
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Trimethylsilyldiazomethane is widely utilized in research focused on:

  • Synthetic Organic Chemistry: This compound is a valuable reagent for the synthesis of various organic compounds, particularly in the formation of carbon-carbon bonds. Its ability to introduce a diazo group makes it useful for creating complex molecular structures.
  • Analytical Chemistry: It serves as a derivatizing agent in gas chromatography, enhancing the detection and analysis of certain compounds. This application is particularly beneficial in environmental and pharmaceutical analysis.
  • Pharmaceutical Development: Trimethylsilyldiazomethane is used in the modification of drug molecules, allowing researchers to explore new therapeutic compounds with improved efficacy and reduced side effects.
  • Material Science: The compound plays a role in the development of novel materials, including polymers and coatings, where its reactivity can be harnessed to improve material properties.
  • Biochemistry: It is applied in the modification of biomolecules, aiding in the study of enzyme mechanisms and protein interactions, which is crucial for understanding biological processes.

Citations