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Catalog Number:
42198
CAS Number:
179324-69-7
Bortezomib
Purity:
≥ 98% (HPLC)
Synonym(s):
(R-3-Methyl-1-[(S-3-phenyl-2-(pyrazine-2-carboxamido)propanamido]butylboronicacid
Documents
$136.00 /10MG
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Product Information

Bortezomib is a potent proteasome inhibitor widely recognized for its critical role in cancer therapy, particularly in the treatment of multiple myeloma and certain types of lymphoma. This compound functions by disrupting the proteasome's activity, leading to the accumulation of pro-apoptotic factors and ultimately inducing cancer cell death. Its unique mechanism of action has made it a cornerstone in targeted cancer treatments, offering significant benefits over traditional chemotherapy by specifically targeting malignant cells while sparing normal tissues.

In addition to its primary use in oncology, Bortezomib is also being explored for its potential applications in various other therapeutic areas, including autoimmune diseases and neurodegenerative disorders. Researchers appreciate its ability to modulate cellular pathways, making it a valuable tool in drug development and clinical research. With its established efficacy and ongoing studies, Bortezomib continues to hold promise for advancing cancer treatment and improving patient outcomes.

Synonyms
(R-3-Methyl-1-[(S-3-phenyl-2-(pyrazine-2-carboxamido)propanamido]butylboronicacid
CAS Number
179324-69-7
Purity
≥ 98% (HPLC)
Molecular Formula
C19H25BN4O4
Molecular Weight
384.24
MDL Number
MFCD09056737
PubChem ID
5213527
Melting Point
123 °C
Density
1.214
Appearance
White to off-white powder
Optical Rotation
a20D = -55 to -50 ° (C=1 in MeOH)
Conditions
Store at ≤ -10 °C
General Information
Synonyms
(R-3-Methyl-1-[(S-3-phenyl-2-(pyrazine-2-carboxamido)propanamido]butylboronicacid
CAS Number
179324-69-7
Purity
≥ 98% (HPLC)
Molecular Formula
C19H25BN4O4
Molecular Weight
384.24
MDL Number
MFCD09056737
PubChem ID
5213527
Melting Point
123 °C
Density
1.214
Appearance
White to off-white powder
Optical Rotation
a20D = -55 to -50 ° (C=1 in MeOH)
Conditions
Store at ≤ -10 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Bortezomib is widely utilized in research focused on:

  • Cancer Treatment: Primarily used in the treatment of multiple myeloma and certain types of lymphoma, Bortezomib inhibits proteasome activity, leading to cancer cell death.
  • Drug Development: Researchers are exploring Bortezomib’s potential in combination therapies to enhance efficacy against resistant cancer strains, making it a key compound in oncology drug research.
  • Biomarker Studies: It serves as a valuable tool in identifying biomarkers for cancer progression and treatment response, aiding in personalized medicine approaches.
  • Neurodegenerative Disease Research: Bortezomib is being investigated for its effects on neurodegenerative diseases, such as Alzheimer's, due to its ability to modulate protein degradation pathways.
  • Veterinary Medicine: There is ongoing research into the use of Bortezomib in treating certain cancers in animals, providing insights into its broader applications beyond human medicine.

Citations