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Catalog Number:
41950
CAS Number:
104821-25-2
Dihydroethidium
Grade:
suitable for Hematology & Histology
Purity:
≥ 95% (NMR)
Synonym(s):
2,7-Diamino-10-ethyl-9-phenyl-9,10-dihydrophenanthridine, 3,8-Diamino-5,6-dihydro-5-ethyl-6-phenylphenanthridine, Hydroethidine
Documents
$208.31 /10MG
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Product Information

Dihydroethidium is a versatile fluorescent compound widely utilized in biological and chemical research, particularly in the study of reactive oxygen species (ROS) and cellular oxidative stress. This compound is recognized for its ability to selectively stain live cells, allowing researchers to visualize and quantify oxidative stress in real-time. Its unique properties enable it to penetrate cell membranes and react with superoxide anions, producing a bright fluorescent signal that can be easily detected using fluorescence microscopy or flow cytometry.

In addition to its applications in oxidative stress research, Dihydroethidium has been employed in various fields, including pharmacology and toxicology, to assess the effects of drugs and environmental toxins on cellular health. Its specificity and sensitivity make it an invaluable tool for researchers aiming to understand the mechanisms of diseases associated with oxidative damage, such as neurodegenerative disorders and cancer. By providing clear insights into cellular processes, Dihydroethidium supports advancements in therapeutic strategies and drug development.

Synonyms
2,7-Diamino-10-ethyl-9-phenyl-9,10-dihydrophenanthridine, 3,8-Diamino-5,6-dihydro-5-ethyl-6-phenylphenanthridine, Hydroethidine
CAS Number
104821-25-2
Purity
≥ 95% (NMR)
Grade
suitable for Hematology & Histology
Molecular Formula
C21H21N3
Molecular Weight
315.41
MDL Number
MFCD00077335
PubChem ID
128682
Appearance
Pink or very dark red powder
Conditions
Store at ≤ -10 °C
General Information
Synonyms
2,7-Diamino-10-ethyl-9-phenyl-9,10-dihydrophenanthridine, 3,8-Diamino-5,6-dihydro-5-ethyl-6-phenylphenanthridine, Hydroethidine
CAS Number
104821-25-2
Purity
≥ 95% (NMR)
Grade
suitable for Hematology & Histology
Molecular Formula
C21H21N3
Molecular Weight
315.41
MDL Number
MFCD00077335
PubChem ID
128682
Appearance
Pink or very dark red powder
Conditions
Store at ≤ -10 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Dihydroethidium is widely utilized in research focused on:

  • Cellular Imaging: This compound is frequently used as a fluorescent probe to visualize reactive oxygen species (ROS) in live cells, helping researchers study oxidative stress and its implications in various diseases.
  • Neuroscience Research: Dihydroethidium is employed to investigate neurodegenerative conditions by tracking oxidative damage in neuronal cells, providing insights into potential therapeutic targets.
  • Cardiovascular Studies: In cardiology, it aids in assessing oxidative stress in heart tissues, allowing for a better understanding of heart diseases and the development of antioxidant therapies.
  • Drug Development: The compound is used in pharmacological studies to evaluate the efficacy of new drugs aimed at reducing oxidative stress, which is linked to numerous health issues.
  • Environmental Monitoring: Dihydroethidium can be applied in studies assessing the impact of pollutants on cellular health, providing valuable data for environmental research and public health initiatives.

Citations