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Catalog Number:
41704
Methyl-PEG12-NHS ester
Synonym(s):
N-Succinimidyl4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxaoctatriacontanoate, 4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxaoctatriacontanoic acidN-succinimidyl ester, mPEG12-NHS ester
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$283.93 /25MG
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Product Information

Methyl-PEG12-NHS ester is a versatile and highly functional reagent widely utilized in bioconjugation and drug delivery applications. This compound features a polyethylene glycol (PEG) backbone, which enhances solubility and biocompatibility, making it an ideal choice for researchers and industry professionals looking to improve the pharmacokinetics of therapeutic agents. The NHS (N-hydroxysuccinimide) ester functionality allows for efficient coupling to amine-containing biomolecules, facilitating the formation of stable linkages in various bioconjugation processes.

This compound is particularly beneficial in the development of antibody-drug conjugates (ADCs) and other targeted therapies, where precise control over the drug-to-antibody ratio is crucial for efficacy and safety. Additionally, Methyl-PEG12-NHS ester can be employed in the creation of functionalized surfaces for biosensors and drug delivery systems, enhancing the performance and specificity of these applications. Its unique properties make it a valuable tool in the fields of pharmaceuticals, biotechnology, and materials science, providing researchers with the means to innovate and optimize their projects effectively.

Synonyms
N-Succinimidyl4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxaoctatriacontanoate, 4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxaoctatriacontanoic acidN-succinimidyl ester, mPEG12-NHS ester
Molecular Formula
C30H55NO16
Molecular Weight
685.76
Appearance
White to off-white powder
Conditions
Store at ≤ -4 °C
General Information
Synonyms
N-Succinimidyl4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxaoctatriacontanoate, 4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxaoctatriacontanoic acidN-succinimidyl ester, mPEG12-NHS ester
Molecular Formula
C30H55NO16
Molecular Weight
685.76
Appearance
White to off-white powder
Conditions
Store at ≤ -4 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Methyl-PEG12-NHS ester is widely utilized in research focused on:

  • Bioconjugation: This compound is commonly used to link biomolecules, such as proteins or antibodies, to surfaces or other molecules, enhancing the stability and functionality of therapeutic agents.
  • Drug Delivery Systems: Its properties allow for the creation of advanced drug delivery systems, improving the solubility and bioavailability of poorly soluble drugs, which is crucial in pharmaceutical development.
  • Diagnostics: Methyl-PEG12-NHS ester plays a significant role in the development of diagnostic assays by facilitating the attachment of detection molecules to surfaces, thereby increasing sensitivity and accuracy.
  • Surface Modification: This chemical is used to modify surfaces of medical devices and implants, reducing protein adsorption and improving biocompatibility, which is essential for patient safety.
  • Research Applications: It is frequently employed in various research settings to create customized materials for studying cellular interactions and drug responses, providing valuable insights into biological processes.

Citations