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Catalog Number:
40415
CAS Number:
400-53-3
Trimethylsilyl trifluoroacetate
Purity:
≥ 95% (GC)
Synonym(s):
Trifluoroacetic acid trimethylsilyl ester
Hazmat
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$38.00 /5G
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Product Information

Trimethylsilyl trifluoroacetate is a versatile reagent widely utilized in organic synthesis and analytical chemistry. This compound serves as an effective silylating agent, enhancing the stability and volatility of various organic compounds, which is particularly beneficial in gas chromatography and mass spectrometry applications. Its ability to form stable derivatives allows for improved detection and quantification of alcohols, amines, and carboxylic acids, making it an essential tool for researchers in both academic and industrial laboratories.

In addition to its analytical applications, Trimethylsilyl trifluoroacetate is also employed in the synthesis of complex organic molecules, including pharmaceuticals and agrochemicals. Its unique trifluoroacetate group provides enhanced reactivity, facilitating various transformations such as esterification and acylation. This compound stands out for its ease of use and compatibility with a wide range of substrates, making it a preferred choice for chemists seeking reliable and efficient reagents in their synthetic pathways.

Synonyms
Trifluoroacetic acid trimethylsilyl ester
CAS Number
400-53-3
Purity
≥ 95% (GC)
Molecular Formula
C5H9F3O2Si
Molecular Weight
0
MDL Number
MFCD00000413
PubChem ID
67863
Density
1.07 g/mL
Appearance
Colorless to yellow clear liquid
Boiling Point
90 °C (Lit.)
Refractive Index
n20D 1.34
Conditions
Store at RT
General Information
Synonyms
Trifluoroacetic acid trimethylsilyl ester
CAS Number
400-53-3
Purity
≥ 95% (GC)
Molecular Formula
C5H9F3O2Si
Molecular Weight
0
MDL Number
MFCD00000413
PubChem ID
67863
Density
1.07 g/mL
Appearance
Colorless to yellow clear liquid
Boiling Point
90 °C (Lit.)
Refractive Index
n20D 1.34
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Trimethylsilyl trifluoroacetate is widely utilized in research focused on:

  • Organic Synthesis: This compound serves as a versatile reagent in organic chemistry, particularly for the protection of alcohols and amines, facilitating smoother synthesis processes.
  • Analytical Chemistry: It is commonly used in mass spectrometry as a derivatizing agent, enhancing the detection and analysis of various compounds, which is crucial for accurate results in research laboratories.
  • Pharmaceutical Development: In drug formulation, it aids in the modification of drug molecules to improve their stability and bioavailability, making it essential for pharmaceutical researchers.
  • Polymer Chemistry: The compound is employed in the synthesis of siloxane-based polymers, which are used in a variety of applications, including coatings and sealants, due to their durability and resistance to environmental factors.
  • Environmental Analysis: It is utilized in the extraction and analysis of pollutants from environmental samples, helping researchers monitor and address contamination issues effectively.

Citations