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Catalog Number:
40241
CAS Number:
168267-41-2
3,4-Difluorophenylboronic acid
Purity:
95 - 105% (Assay by titration)
Synonym(s):
3,4-Difluorobenzeneboronic acid
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Product Information

3,4-Difluorophenylboronic acid is a versatile compound widely utilized in organic synthesis and medicinal chemistry. This boronic acid derivative is recognized for its unique ability to form stable complexes with diols, making it an essential reagent in the development of various pharmaceuticals and agrochemicals. Its fluorinated structure enhances its reactivity and selectivity, allowing for precise modifications in complex molecular architectures. Researchers often employ 3,4-difluorophenylboronic acid in Suzuki-Miyaura cross-coupling reactions, which are pivotal in constructing biaryl compounds that serve as key intermediates in drug discovery and material science.

In addition to its synthetic applications, this compound has shown promise in the development of targeted therapies, particularly in oncology, where it can be used to modify drug delivery systems. Its unique properties enable the creation of more effective therapeutic agents with improved bioavailability and reduced side effects. With its growing relevance in cutting-edge research and industrial applications, 3,4-difluorophenylboronic acid stands out as a valuable tool for chemists and researchers aiming to innovate in their respective fields.

Synonyms
3,4-Difluorobenzeneboronic acid
CAS Number
168267-41-2
Purity
95 - 105% (Assay by titration)
Molecular Formula
C6H5BF2O2
Molecular Weight
157.91
MDL Number
MFCD00807405
PubChem ID
2734337
Melting Point
310 °C (Lit.)
Appearance
White to off-white crystalline powder
Conditions
Store at RT
General Information
Synonyms
3,4-Difluorobenzeneboronic acid
CAS Number
168267-41-2
Purity
95 - 105% (Assay by titration)
Molecular Formula
C6H5BF2O2
Molecular Weight
157.91
MDL Number
MFCD00807405
PubChem ID
2734337
Melting Point
310 °C (Lit.)
Appearance
White to off-white crystalline powder
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

3,4-Difluorophenylboronic acid is widely utilized in research focused on:

  • Pharmaceutical Development: This compound serves as a key intermediate in the synthesis of various pharmaceuticals, particularly in the development of drugs targeting cancer and other diseases. Its unique fluorine substitutions enhance biological activity and selectivity.
  • Organic Synthesis: It is employed in cross-coupling reactions, such as Suzuki-Miyaura coupling, to create complex organic molecules. This application is crucial in the production of agrochemicals and fine chemicals, offering a versatile tool for chemists.
  • Material Science: The compound is used in the development of advanced materials, including polymers and nanomaterials. Its boronic acid functionality allows for the formation of dynamic covalent bonds, leading to innovative material properties.
  • Bioconjugation: In biochemistry, it is utilized for labeling biomolecules, enabling researchers to track and study biological processes. This application is particularly beneficial in drug delivery systems and diagnostic tools.
  • Environmental Chemistry: 3,4-Difluorophenylboronic acid is also explored for its potential in environmental applications, such as the detection and removal of pollutants, due to its reactivity with various environmental contaminants.

Citations