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Catalog Number:
40127
CAS Number:
175676-65-0
2-(Trifluoromethoxy)phenylboronic acid
Purity:
95 - 105% (Assay by titration)
Synonym(s):
2-(Trifluoromethoxy)benzeneboronic acid
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Product Information

2-(Trifluoromethoxy)phenylboronic acid is a versatile compound widely utilized in organic synthesis and medicinal chemistry. This boronic acid derivative is particularly valued for its ability to participate in Suzuki-Miyaura cross-coupling reactions, making it an essential building block for the development of complex organic molecules. Its trifluoromethoxy group enhances its reactivity and solubility, allowing for efficient coupling with various electrophiles, which is crucial in the synthesis of pharmaceuticals and agrochemicals. Researchers have leveraged this compound in the synthesis of biologically active compounds, including potential drug candidates, due to its unique electronic properties and stability.

In addition to its synthetic applications, 2-(Trifluoromethoxy)phenylboronic acid has shown promise in the field of materials science, particularly in the development of advanced polymers and functional materials. Its ability to form stable complexes with diols and other Lewis bases opens avenues for creating novel materials with tailored properties. This compound stands out among similar boronic acids due to its trifluoromethoxy substituent, which imparts distinct advantages in both reactivity and selectivity, making it a valuable asset for researchers and industry professionals alike.

Synonyms
2-(Trifluoromethoxy)benzeneboronic acid
CAS Number
175676-65-0
Purity
95 - 105% (Assay by titration)
Molecular Formula
C7H6BF3O3
Molecular Weight
205.93
MDL Number
MFCD01320763
PubChem ID
2777204
Melting Point
118 °C (Lit.)
Appearance
White to light yellow crystalline powder
Conditions
Store at RT
General Information
Synonyms
2-(Trifluoromethoxy)benzeneboronic acid
CAS Number
175676-65-0
Purity
95 - 105% (Assay by titration)
Molecular Formula
C7H6BF3O3
Molecular Weight
205.93
MDL Number
MFCD01320763
PubChem ID
2777204
Melting Point
118 °C (Lit.)
Appearance
White to light yellow crystalline powder
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

2-(Trifluoromethoxy)phenylboronic acid is widely utilized in research focused on:

  • Medicinal Chemistry: This compound serves as a crucial building block in the synthesis of various pharmaceuticals, particularly in developing drugs targeting cancer and metabolic disorders.
  • Organic Synthesis: It is employed in cross-coupling reactions, such as Suzuki-Miyaura coupling, to create complex organic molecules, making it valuable for researchers in organic chemistry.
  • Material Science: The compound is used to modify surfaces and enhance the properties of polymers, contributing to the development of advanced materials with improved performance.
  • Agricultural Chemistry: It plays a role in the formulation of agrochemicals, aiding in the development of effective herbicides and pesticides that are more environmentally friendly.
  • Analytical Chemistry: This chemical is utilized in developing sensors and detection methods for various analytes, providing researchers with reliable tools for environmental monitoring and quality control.

Citations