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Catalog Number:
38436
CAS Number:
14222-60-7
Prothionamide
Purity:
≥ 98% (HPLC)
Synonym(s):
2-Propylpyridine-4-carbothioamide, 2-Propylthioisonicotinamide
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Product Information

Prothionamide is a potent thioamide compound primarily utilized in the treatment of tuberculosis, particularly in cases resistant to first-line therapies. This compound acts by inhibiting the synthesis of mycolic acids, essential components of the bacterial cell wall, thereby effectively combating Mycobacterium tuberculosis. Its unique mechanism of action makes it a valuable addition to multidrug regimens, especially for patients who have not responded to conventional treatments.

In addition to its therapeutic applications, Prothionamide is also of interest in research settings, where it is studied for its potential in developing new anti-tubercular agents. Its favorable pharmacokinetic properties, including good oral bioavailability and a manageable side effect profile, enhance its appeal in clinical settings. Researchers and healthcare professionals appreciate Prothionamide for its role in addressing the growing challenge of drug-resistant tuberculosis, making it a critical component in the ongoing fight against this global health issue.

Synonyms
2-Propylpyridine-4-carbothioamide, 2-Propylthioisonicotinamide
CAS Number
14222-60-7
Purity
≥ 98% (HPLC)
Molecular Formula
C9H12N2S
Molecular Weight
180.27
MDL Number
MFCD00464119
PubChem ID
666418
Melting Point
141 - 145 °C
Appearance
Light yellow to yellow to orange powder to crystal
Conditions
Store at < -20 °C
General Information
Synonyms
2-Propylpyridine-4-carbothioamide, 2-Propylthioisonicotinamide
CAS Number
14222-60-7
Purity
≥ 98% (HPLC)
Molecular Formula
C9H12N2S
Molecular Weight
180.27
MDL Number
MFCD00464119
PubChem ID
666418
Melting Point
141 - 145 °C
Appearance
Light yellow to yellow to orange powder to crystal
Conditions
Store at < -20 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Prothionamide is widely utilized in research focused on

  • Tuberculosis Treatment: This compound is primarily used as an anti-tubercular agent, particularly for treating multidrug-resistant tuberculosis. It enhances treatment options for patients who do not respond to standard therapies.
  • Pharmaceutical Development: Researchers are exploring prothionamide's efficacy in combination therapies, which can improve treatment outcomes and reduce the duration of therapy for various bacterial infections.
  • Drug Resistance Studies: Prothionamide serves as a valuable tool in studying mechanisms of drug resistance in Mycobacterium tuberculosis, helping scientists develop new strategies to combat resistant strains.
  • Research in Infectious Diseases: Its application extends to laboratory studies aimed at understanding the pharmacokinetics and pharmacodynamics of anti-tubercular drugs, providing insights into optimizing treatment regimens.
  • Public Health Initiatives: Prothionamide is critical in public health efforts to control tuberculosis outbreaks, especially in high-burden countries, by offering effective treatment alternatives.

Citations