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Catalog Number:
38410
CAS Number:
187235-37-6
PA-824
Purity:
≥ 98% (HPLC)
Synonym(s):
Pretomanid, (S)-2-Nitro-6-[[4-(trifluoromethoxy)benzyl]oxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
Documents
$332.80 /25MG
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Product Information

PA-824 is a potent nitroimidazoles compound recognized for its significant role in tuberculosis (TB) treatment, particularly in combating multidrug-resistant strains. This compound exhibits unique properties that enhance its efficacy as an anti-TB agent, making it a valuable asset in the pharmaceutical industry. PA-824 operates through a novel mechanism of action that involves the activation of its nitro group under anaerobic conditions, leading to the selective killing of Mycobacterium tuberculosis. Its ability to penetrate macrophages and target dormant bacteria positions PA-824 as a promising candidate for both current and future TB therapies.

In addition to its primary application in tuberculosis, PA-824 is also being explored for its potential in treating other infectious diseases and as a lead compound for developing new antimycobacterial agents. Researchers appreciate its favorable pharmacokinetic profile, which allows for effective dosing regimens. The compound's unique trifluoromethoxy group contributes to its stability and bioactivity, setting it apart from similar compounds. With ongoing studies and clinical trials, PA-824 holds the potential to significantly impact global health by addressing the urgent need for effective TB treatments.

Synonyms
Pretomanid, (S)-2-Nitro-6-[[4-(trifluoromethoxy)benzyl]oxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
CAS Number
187235-37-6
Purity
≥ 98% (HPLC)
Molecular Formula
C14H12F3N3O5
Molecular Weight
359.26
MDL Number
MFCD06809939
PubChem ID
21062558
Melting Point
148 - 152 °C
Appearance
White to almost white powder to crystal
Optical Rotation
-44 to -49 ° (C=1, MeOH)
Conditions
Store at < -20 °C
General Information
Synonyms
Pretomanid, (S)-2-Nitro-6-[[4-(trifluoromethoxy)benzyl]oxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
CAS Number
187235-37-6
Purity
≥ 98% (HPLC)
Molecular Formula
C14H12F3N3O5
Molecular Weight
359.26
MDL Number
MFCD06809939
PubChem ID
21062558
Melting Point
148 - 152 °C
Appearance
White to almost white powder to crystal
Optical Rotation
-44 to -49 ° (C=1, MeOH)
Conditions
Store at < -20 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

PA-824 is widely utilized in research focused on

  • Tuberculosis Treatment: This compound is primarily studied for its effectiveness against drug-resistant strains of tuberculosis, offering hope for more effective therapies.
  • Antimicrobial Research: Researchers are exploring its potential as a broad-spectrum antimicrobial agent, which could lead to new treatments for various infections.
  • Pharmaceutical Development: PA-824 serves as a lead compound in the development of new medications, particularly in the field of infectious diseases, enhancing drug discovery efforts.
  • Mechanistic Studies: It is used in laboratory settings to understand the mechanisms of action of nitroimidazole compounds, aiding in the design of next-generation antibiotics.
  • Combination Therapies: The compound is being investigated for use in combination with other drugs to improve treatment outcomes for patients with complex infections.

Citations