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Catalog Number:
38367
CAS Number:
3690-10-6
Zebularine
Purity:
≥ 95% (HPLC)
Synonym(s):
4-Deoxyuridine, 1-(b-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one
Documents
$186.98 /200MG
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Product Information

Zebularine is a versatile nucleoside analog that has garnered significant attention in the fields of molecular biology and medicinal chemistry. This compound is recognized for its ability to inhibit DNA methyltransferases, making it a valuable tool in epigenetic research and cancer therapy. Zebularine's unique structure allows it to integrate into DNA, leading to hypomethylation and reactivation of silenced genes, which can be particularly beneficial in the study of gene expression and regulation. Researchers have utilized Zebularine in various applications, including the development of novel cancer treatments and the exploration of epigenetic modifications in stem cell biology. Its potential to enhance the efficacy of existing therapies by targeting epigenetic mechanisms positions Zebularine as a promising candidate for future therapeutic strategies.

In addition to its research applications, Zebularine is also being investigated for its role in improving the effectiveness of gene therapy approaches. By modulating the epigenetic landscape, it may help in overcoming resistance to conventional treatments, thereby expanding its utility in clinical settings. With its ability to influence gene expression and its relatively low toxicity, Zebularine stands out as a significant compound for researchers and industry professionals focused on innovative therapeutic solutions.

Synonyms
4-Deoxyuridine, 1-(b-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one
CAS Number
3690-10-6
Purity
≥ 95% (HPLC)
Molecular Formula
C9H12N2O5
Molecular Weight
228.2
MDL Number
MFCD04973699
PubChem ID
328839
Melting Point
161 - 163 °C (Lit.)
Appearance
White solid
Optical Rotation
[a]D20 = 163 ± 1 ° (C=1 in Water)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
4-Deoxyuridine, 1-(b-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one
CAS Number
3690-10-6
Purity
≥ 95% (HPLC)
Molecular Formula
C9H12N2O5
Molecular Weight
228.2
MDL Number
MFCD04973699
PubChem ID
328839
Melting Point
161 - 163 °C (Lit.)
Appearance
White solid
Optical Rotation
[a]D20 = 163 ± 1 ° (C=1 in Water)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Zebularine is widely utilized in research focused on:

  • Cancer Research: Zebularine has shown promise as a hypomethylating agent, which can help reactivate silenced tumor suppressor genes, making it a valuable tool in developing cancer therapies.
  • Epigenetics: This compound is used to study DNA methylation processes, providing insights into gene regulation and the potential for therapeutic interventions in various diseases.
  • Drug Development: Researchers are exploring zebularine's ability to enhance the effectiveness of existing chemotherapeutic agents, potentially leading to more effective treatment regimens for cancer patients.
  • Gene Therapy: Zebularine's role in modifying epigenetic markers makes it a candidate for gene therapy applications, particularly in conditions where gene expression needs to be altered.
  • Neuroscience: Studies indicate that zebularine may influence neuronal differentiation and survival, suggesting potential applications in neurodegenerative disease research.

Citations