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Catalog Number:
38343
CAS Number:
134308-13-7
Tolcapone
Purity:
≥ 98% (HPLC)
Synonym(s):
3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
Documents
$314.87 /50MG
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Product Information

Tolcapone is a potent and selective inhibitor of catechol-O-methyltransferase (COMT), primarily utilized in the treatment of Parkinson's disease. This compound enhances the bioavailability of levodopa, a common medication for Parkinson's, by preventing its metabolism, thereby improving motor function and reducing the "off" time experienced by patients. Its unique mechanism of action allows for more stable and prolonged therapeutic effects compared to other COMT inhibitors, making it a valuable option in managing Parkinson's symptoms.

In addition to its clinical applications, Tolcapone is also of interest in research settings, particularly in studies exploring neurodegenerative diseases and the pharmacokinetics of dopaminergic therapies. Its ability to cross the blood-brain barrier effectively positions it as a critical compound for investigations into brain chemistry and the development of novel therapeutic strategies. Researchers and healthcare professionals can leverage Tolcapone's properties to enhance treatment regimens and contribute to advancements in Parkinson's disease management.

Synonyms
3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
CAS Number
134308-13-7
Purity
≥ 98% (HPLC)
Molecular Formula
C14H11NO5
Molecular Weight
273.24
MDL Number
MFCD00866569
PubChem ID
4659569
Melting Point
142 - 146 °C
Appearance
White to yellow to green powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
CAS Number
134308-13-7
Purity
≥ 98% (HPLC)
Molecular Formula
C14H11NO5
Molecular Weight
273.24
MDL Number
MFCD00866569
PubChem ID
4659569
Melting Point
142 - 146 °C
Appearance
White to yellow to green powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Tolcapone is widely utilized in research focused on:

  • Parkinson's Disease Treatment: It is primarily used as a medication to manage symptoms of Parkinson's disease by inhibiting the enzyme catechol-O-methyltransferase (COMT), which helps increase dopamine levels in the brain.
  • Pharmaceutical Development: Researchers explore tolcapone's efficacy in combination therapies, enhancing the effectiveness of other Parkinson's treatments, thus improving patient outcomes.
  • Neuroscience Research: It serves as a valuable tool in studying dopamine-related pathways, aiding scientists in understanding neurodegenerative disorders and developing new therapeutic strategies.
  • Drug Interaction Studies: Tolcapone is used in clinical trials to assess its interactions with other medications, providing insights into safe and effective combinations for patients.
  • Biomarker Identification: In research settings, tolcapone helps identify biomarkers for Parkinson's disease progression, assisting in the development of diagnostic tools and personalized medicine approaches.

Citations