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Catalog Number:
38337
CAS Number:
64-77-7
Tolbutamide
Purity:
≥ 98% (HPLC)
Synonym(s):
N-(Butylcarbamoyl)-4-methylbenzenesulfonamide, 1-Butyl-3-(4-methylphenylsulfonyl)urea
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Product Information

Tolbutamide is a well-established sulfonylurea compound primarily utilized in the management of type 2 diabetes mellitus. This medication works by stimulating insulin secretion from the pancreas, thereby effectively lowering blood glucose levels. With its rapid onset of action, Tolbutamide is particularly beneficial for patients who require immediate glycemic control. It is often prescribed in conjunction with dietary management and exercise to enhance overall metabolic health.

In addition to its primary use in diabetes treatment, Tolbutamide has been explored in various research settings for its potential applications in pharmacology and metabolic studies. Its unique mechanism of action makes it a valuable compound for researchers investigating insulin sensitivity and pancreatic function. The compound's favorable safety profile and established efficacy make it a preferred choice among healthcare professionals for managing blood sugar levels in diabetic patients.

Synonyms
N-(Butylcarbamoyl)-4-methylbenzenesulfonamide, 1-Butyl-3-(4-methylphenylsulfonyl)urea
CAS Number
64-77-7
Purity
≥ 98% (HPLC)
Molecular Formula
C12H18N2O3S
Molecular Weight
270.35
MDL Number
MFCD00027169
PubChem ID
5505
Melting Point
126 - 130 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
N-(Butylcarbamoyl)-4-methylbenzenesulfonamide, 1-Butyl-3-(4-methylphenylsulfonyl)urea
CAS Number
64-77-7
Purity
≥ 98% (HPLC)
Molecular Formula
C12H18N2O3S
Molecular Weight
270.35
MDL Number
MFCD00027169
PubChem ID
5505
Melting Point
126 - 130 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Tolbutamide is widely utilized in research focused on:

  • Diabetes Management: This compound is primarily used as an oral hypoglycemic agent to help control blood sugar levels in patients with type 2 diabetes. It stimulates insulin release from the pancreas, making it a vital medication in diabetes care.
  • Pharmaceutical Research: Researchers often study tolbutamide to understand its mechanisms and effects on glucose metabolism, which can lead to the development of new diabetes treatments or improved formulations.
  • Drug Interaction Studies: Tolbutamide serves as a model compound in pharmacokinetic studies to investigate how different drugs interact with metabolic pathways, providing insights that can enhance patient safety and efficacy of treatments.
  • Clinical Trials: It is frequently included in clinical trials aimed at evaluating new diabetes therapies, helping to establish benchmarks for efficacy and safety against established treatments.
  • Education and Training: In academic settings, tolbutamide is used in pharmacology and medicinal chemistry courses to teach students about sulfonylureas and their role in managing diabetes, enriching their understanding of drug mechanisms.

Citations