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Catalog Number:
38330
CAS Number:
133550-37-5
Tyrphostin AG 835
Purity:
≥ 98% (HPLC)
Synonym(s):
(S)-N-(a-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide, (S)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)acrylamide
Documents
$226.94 /25MG
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Product Information

Tyrphostin AG 835 is a potent and selective inhibitor of receptor tyrosine kinases, particularly known for its role in cancer research and therapeutic applications. This compound has gained significant attention due to its ability to modulate cellular signaling pathways, making it a valuable tool for researchers investigating the mechanisms of tumor growth and metastasis. Its unique structure, featuring a cyano group and a phenylethyl moiety, contributes to its specificity and efficacy in inhibiting target kinases.

In practical applications, Tyrphostin AG 835 has been utilized in various studies aimed at understanding cancer cell proliferation and survival. It has shown promise in enhancing the effectiveness of existing chemotherapeutic agents, thereby improving treatment outcomes. Additionally, its role in studying angiogenesis and cell migration makes it an essential compound for researchers focused on developing innovative cancer therapies. With its targeted action and potential to advance cancer treatment strategies, Tyrphostin AG 835 stands out as a critical resource for both academic and industrial applications.

Synonyms
(S)-N-(a-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide, (S)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)acrylamide
CAS Number
133550-37-5
Purity
≥ 98% (HPLC)
Molecular Formula
C18H16N2O3
Molecular Weight
308.34
MDL Number
MFCD00209855
PubChem ID
2056
Melting Point
145 - 147 °C
Appearance
Light yellow to amber to dark green powder to crystal
Optical Rotation
=+93.0 to +98.0 deg(C=0.5,MeOH)
Conditions
Store at <0°C
General Information
Synonyms
(S)-N-(a-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide, (S)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)acrylamide
CAS Number
133550-37-5
Purity
≥ 98% (HPLC)
Molecular Formula
C18H16N2O3
Molecular Weight
308.34
MDL Number
MFCD00209855
PubChem ID
2056
Melting Point
145 - 147 °C
Appearance
Light yellow to amber to dark green powder to crystal
Optical Rotation
=+93.0 to +98.0 deg(C=0.5,MeOH)
Conditions
Store at <0°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Tyrphostin AG 835 is widely utilized in research focused on:

  • Cancer Research: It acts as a selective inhibitor of certain receptor tyrosine kinases, making it valuable in studying cancer cell proliferation and survival mechanisms.
  • Neuroscience: This compound is used to investigate the role of growth factor signaling in neuronal survival and differentiation, aiding in the understanding of neurodegenerative diseases.
  • Drug Development: As a lead compound, it serves as a template for designing new therapeutic agents targeting specific kinases, enhancing the efficiency of drug discovery processes.
  • Cell Biology: Researchers employ it to dissect signaling pathways in various cell types, providing insights into cellular responses to growth factors and hormones.
  • Pharmaceutical Formulations: Its properties allow for the development of targeted therapies, improving treatment outcomes in conditions like diabetes and cancer by modulating specific signaling pathways.

Citations