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Catalog Number:
38247
CAS Number:
52-01-7
Spironolactone
Grade:
Meets USP specification
Purity:
97.0 - 103.0% (HPLC)
Synonym(s):
4-Pregnen-21-oic acid-17a-ol-3-one-7a-thiol g-lactone 7-acetate, 7a-(Acetylthio)-17a-hydroxy-3-oxopregn-4-ene-21-carboxylic acidg-lactone
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Product Information

Spironolactone is a potent diuretic and anti-androgen medication widely used in the treatment of conditions such as hypertension, heart failure, and edema. This compound functions by antagonizing aldosterone receptors, leading to increased sodium and water excretion while preserving potassium. Its unique structure allows it to effectively manage fluid retention and hypertension, making it a valuable asset in cardiovascular health. Additionally, spironolactone is employed in the management of hormonal acne and polycystic ovary syndrome (PCOS), showcasing its versatility in both medical and dermatological applications.

Researchers and healthcare professionals appreciate spironolactone for its dual action as both a diuretic and an anti-androgen, providing a multifaceted approach to treatment. Its ability to balance electrolytes while promoting diuresis sets it apart from other diuretics, making it a preferred choice in various therapeutic regimens. With ongoing studies exploring its potential benefits in other areas, spironolactone continues to hold promise for future applications in medicine.

Synonyms
4-Pregnen-21-oic acid-17a-ol-3-one-7a-thiol g-lactone 7-acetate, 7a-(Acetylthio)-17a-hydroxy-3-oxopregn-4-ene-21-carboxylic acidg-lactone
CAS Number
52-01-7
Purity
97.0 - 103.0% (HPLC)
Grade
Meets USP specification
Molecular Formula
C24H32O4S
Molecular Weight
416.58
MDL Number
MFCD00082250
PubChem ID
5267
Melting Point
198 - 209 °C
Appearance
White to off-white tan crystalline powder
Optical Rotation
[a]D20 = -41 to -45 °
Conditions
Store at 0 - 8 °C
General Information
Synonyms
4-Pregnen-21-oic acid-17a-ol-3-one-7a-thiol g-lactone 7-acetate, 7a-(Acetylthio)-17a-hydroxy-3-oxopregn-4-ene-21-carboxylic acidg-lactone
CAS Number
52-01-7
Purity
97.0 - 103.0% (HPLC)
Grade
Meets USP specification
Molecular Formula
C24H32O4S
Molecular Weight
416.58
MDL Number
MFCD00082250
PubChem ID
5267
Melting Point
198 - 209 °C
Appearance
White to off-white tan crystalline powder
Optical Rotation
[a]D20 = -41 to -45 °
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Spironolactone is widely utilized in research focused on:

  • Cardiovascular Health: Commonly prescribed for managing conditions like hypertension and heart failure, it helps reduce fluid retention and lower blood pressure, making it essential in cardiology.
  • Hormonal Treatments: Used in treating conditions related to hormonal imbalances, such as polycystic ovary syndrome (PCOS) and certain types of acne, it acts as an anti-androgen, providing relief for patients.
  • Diuretic Applications: As a potassium-sparing diuretic, it is effective in preventing potassium loss while promoting fluid elimination, which is particularly beneficial for patients with kidney issues.
  • Research in Oncology: Investigated for its potential role in cancer treatment, particularly in hormone-sensitive cancers, it offers a promising avenue for therapeutic strategies.
  • Animal Studies: Frequently used in veterinary medicine to manage similar conditions in pets, it highlights its versatility and importance across species.

Citations