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Catalog Number:
38244
CAS Number:
99755-59-6
Rotigotine
Purity:
≥ 98% (Assay by titration, HPLC)
Synonym(s):
(S)-6-[Propyl[2-(thiophen-2-yl)ethyl]amino]-5,6,7,8-tetrahydronaphthalen-1-ol, (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol
Documents
$204.31 /10MG
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Product Information

Rotigotine is a potent dopamine agonist primarily used in the treatment of Parkinson's disease and restless legs syndrome. This compound mimics the action of dopamine, a crucial neurotransmitter, thereby helping to alleviate symptoms associated with these conditions. Its unique formulation allows for transdermal delivery, providing a steady release of medication that enhances patient compliance and comfort. Researchers and healthcare professionals appreciate Rotigotine for its ability to improve motor function and reduce the severity of symptoms, making it a valuable option in neuropharmacology.

In addition to its therapeutic applications, Rotigotine is also being explored for its potential in various research settings, particularly in studies related to neurodegenerative diseases. Its favorable pharmacokinetic profile and minimal side effects compared to other dopamine agonists make it an attractive candidate for further investigation. With ongoing research, Rotigotine holds promise for expanding its use beyond current applications, potentially benefiting a wider range of patients and conditions.

Synonyms
(S)-6-[Propyl[2-(thiophen-2-yl)ethyl]amino]-5,6,7,8-tetrahydronaphthalen-1-ol, (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol
CAS Number
99755-59-6
Purity
≥ 98% (Assay by titration, HPLC)
Molecular Formula
C19H25NOS
Molecular Weight
315.48
MDL Number
MFCD00869590
PubChem ID
57537
Melting Point
77 - 79 °C
Appearance
White to almost white powder to crystal
Optical Rotation
[a]D20 = -34 to -38 ° (C=1, methanol)
Conditions
Store at < 0 °C
General Information
Synonyms
(S)-6-[Propyl[2-(thiophen-2-yl)ethyl]amino]-5,6,7,8-tetrahydronaphthalen-1-ol, (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol
CAS Number
99755-59-6
Purity
≥ 98% (Assay by titration, HPLC)
Molecular Formula
C19H25NOS
Molecular Weight
315.48
MDL Number
MFCD00869590
PubChem ID
57537
Melting Point
77 - 79 °C
Appearance
White to almost white powder to crystal
Optical Rotation
[a]D20 = -34 to -38 ° (C=1, methanol)
Conditions
Store at < 0 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Rotigotine is widely utilized in research focused on:

  • Parkinson's Disease Treatment: Rotigotine is primarily used as a medication for managing symptoms of Parkinson's disease, providing patients with improved motor function and quality of life.
  • Transdermal Delivery Systems: Its formulation as a transdermal patch allows for continuous delivery of the drug, enhancing patient compliance and reducing the need for frequent dosing.
  • Neuroprotective Research: Ongoing studies investigate its potential neuroprotective effects, which may offer benefits in treating other neurodegenerative disorders beyond Parkinson's.
  • Clinical Trials: Rotigotine is often a subject of clinical trials aimed at evaluating its efficacy and safety in various populations, contributing to advancements in treatment protocols.
  • Pharmaceutical Development: The compound serves as a model for developing new drugs targeting dopamine receptors, which is crucial in the field of neuropharmacology.

Citations