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Catalog Number:
38242
CAS Number:
292135-78-5
Roflumilast N-oxide
Purity:
≥ 98% (HPLC)
Synonym(s):
3,5-Dichloro-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamido]pyridine1-Oxide
Documents
$326.39 /5MG
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Product Information

Roflumilast N-oxide is a potent and selective phosphodiesterase-4 (PDE4) inhibitor, primarily utilized in the treatment of chronic obstructive pulmonary disease (COPD) and asthma. This compound is recognized for its ability to reduce inflammation and improve lung function, making it a valuable asset in respiratory therapies. Its unique structure, featuring a cyclopropylmethoxy group and a difluoromethoxy moiety, enhances its pharmacological profile, allowing for effective modulation of inflammatory responses.

In research and clinical settings, Roflumilast N-oxide has demonstrated significant efficacy in alleviating symptoms associated with airway diseases, providing relief for patients who are unresponsive to conventional treatments. Its application extends to the development of combination therapies, where it can synergistically enhance the effects of bronchodilators. With its favorable safety profile and targeted action, Roflumilast N-oxide stands out as a promising candidate for advancing respiratory health and improving patient outcomes.

Synonyms
3,5-Dichloro-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamido]pyridine1-Oxide
CAS Number
292135-78-5
Purity
≥ 98% (HPLC)
Molecular Formula
C17H14Cl2F2N2O4
Molecular Weight
419.21
MDL Number
MFCD04112984
PubChem ID
9940999
Melting Point
179 - 183 °C
Appearance
White to light yellow to light orange powder to crystal
Conditions
Store at < 0 °C
General Information
Synonyms
3,5-Dichloro-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamido]pyridine1-Oxide
CAS Number
292135-78-5
Purity
≥ 98% (HPLC)
Molecular Formula
C17H14Cl2F2N2O4
Molecular Weight
419.21
MDL Number
MFCD04112984
PubChem ID
9940999
Melting Point
179 - 183 °C
Appearance
White to light yellow to light orange powder to crystal
Conditions
Store at < 0 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Roflumilast N-oxide is widely utilized in research focused on:

  • Chronic Obstructive Pulmonary Disease (COPD) Treatment: This compound is a key player in developing medications aimed at reducing inflammation and improving lung function in COPD patients.
  • Anti-inflammatory Research: It serves as a valuable tool in studies investigating the mechanisms of inflammation, helping researchers understand how to better manage inflammatory diseases.
  • Pharmaceutical Development: Roflumilast N-oxide is used in the formulation of new drugs, offering a pathway to create more effective treatments with fewer side effects compared to existing options.
  • Respiratory Health Studies: Researchers utilize this compound to explore its effects on respiratory conditions, contributing to advancements in therapies that enhance patient quality of life.
  • Comparative Effectiveness Research: It allows scientists to compare the efficacy of different anti-inflammatory agents, providing insights that can lead to improved treatment protocols.

Citations