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Catalog Number:
38240
CAS Number:
112887-68-0
Raltitrexed
Purity:
≥ 98% (HPLC)
Synonym(s):
N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic acid, ICI-D-1694
Hazmat
Documents
$334.10 /50MG
Pack Size Availability Price
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Product Information

Raltitrexed is a potent antifolate compound primarily utilized in the treatment of various cancers, particularly colorectal cancer. As a thymidylate synthase inhibitor, it disrupts DNA synthesis, making it an essential agent in chemotherapy regimens. Its unique mechanism of action allows for effective targeting of rapidly dividing cancer cells, providing a valuable option for oncologists seeking to enhance patient outcomes. Raltitrexed is often favored for its ability to overcome resistance to other chemotherapeutic agents, making it a critical component in combination therapies.

In addition to its primary applications in oncology, Raltitrexed has shown promise in research settings, particularly in studies focused on cellular metabolism and the development of novel therapeutic strategies. Its specific structure allows for targeted modifications, which can lead to the development of new derivatives with improved efficacy and reduced side effects. Researchers and industry professionals can leverage Raltitrexed's unique properties to explore innovative treatment avenues and enhance existing cancer therapies.

Synonyms
N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic acid, ICI-D-1694
CAS Number
112887-68-0
Purity
≥ 98% (HPLC)
Molecular Formula
C21H22N4O6S
Molecular Weight
458.49
MDL Number
MFCD00864168
PubChem ID
135450461
Melting Point
176 ?C (dec.)
Appearance
White to light yellow powder to crystal
Optical Rotation
[a]D20 = -15 to -20 ° (C=1 in MeOH)
Conditions
Store at < 0 °C
General Information
Synonyms
N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic acid, ICI-D-1694
CAS Number
112887-68-0
Purity
≥ 98% (HPLC)
Molecular Formula
C21H22N4O6S
Molecular Weight
458.49
MDL Number
MFCD00864168
PubChem ID
135450461
Melting Point
176 ?C (dec.)
Appearance
White to light yellow powder to crystal
Optical Rotation
[a]D20 = -15 to -20 ° (C=1 in MeOH)
Conditions
Store at < 0 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Raltitrexed is widely utilized in research focused on

  • Cancer Treatment: This compound is primarily used as an anti-cancer agent, particularly in the treatment of colorectal cancer. It acts as a thymidylate synthase inhibitor, disrupting DNA synthesis in rapidly dividing cancer cells.
  • Pharmaceutical Development: Raltitrexed serves as a critical reference compound in the development of new anti-cancer drugs. Researchers study its mechanisms to design more effective therapies with fewer side effects.
  • Combination Therapies: It is often used in combination with other chemotherapeutic agents to enhance treatment efficacy. This synergistic approach can improve patient outcomes in various cancer types.
  • Clinical Trials: Raltitrexed is frequently involved in clinical trials aimed at evaluating new treatment regimens. Its established profile helps researchers assess the effectiveness of novel therapeutic strategies.
  • Research on Drug Resistance: Scientists study Raltitrexed to understand mechanisms of drug resistance in cancer cells. Insights gained can lead to the development of strategies to overcome resistance and improve treatment success.

Citations