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Catalog Number:
38222
CAS Number:
61413-54-5
Rolipram
Purity:
≥ 98% (HPLC)
Synonym(s):
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK 62711
Documents
$220.33 /50MG
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Product Information

Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor that has garnered significant attention in the fields of pharmacology and neuroscience. This compound is recognized for its potential therapeutic applications, particularly in the treatment of depression, anxiety disorders, and neurodegenerative diseases. By inhibiting the breakdown of cyclic adenosine monophosphate (cAMP), Rolipram enhances intracellular signaling pathways, which can lead to improved mood and cognitive function. Its unique ability to cross the blood-brain barrier makes it particularly valuable for neurological research and drug development.

In addition to its applications in mental health, Rolipram has been studied for its anti-inflammatory properties, showing promise in conditions such as asthma and chronic obstructive pulmonary disease (COPD). Researchers are exploring its potential in enhancing memory and learning, making it a compound of interest in cognitive enhancement studies. With its specific action on PDE4, Rolipram stands out among similar compounds, offering targeted therapeutic benefits with a favorable safety profile. This makes it an essential candidate for researchers and industry professionals focused on innovative treatments for complex disorders.

Synonyms
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK 62711
CAS Number
61413-54-5
Purity
≥ 98% (HPLC)
Molecular Formula
C16H21NO3
Molecular Weight
275.35
MDL Number
MFCD00270906
PubChem ID
5092
Melting Point
130 - 134 °C
Appearance
White to orange to green powder to crystal
Conditions
Store at < -20 °C
General Information
Synonyms
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK 62711
CAS Number
61413-54-5
Purity
≥ 98% (HPLC)
Molecular Formula
C16H21NO3
Molecular Weight
275.35
MDL Number
MFCD00270906
PubChem ID
5092
Melting Point
130 - 134 °C
Appearance
White to orange to green powder to crystal
Conditions
Store at < -20 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Rolipram is widely utilized in research focused on:

  • Neuropharmacology: It acts as a selective phosphodiesterase-4 (PDE4) inhibitor, which can enhance cognitive function and has potential applications in treating neurodegenerative diseases like Alzheimer's.
  • Anti-inflammatory therapies: By inhibiting PDE4, Rolipram reduces the production of pro-inflammatory cytokines, making it a candidate for developing treatments for chronic inflammatory conditions such as asthma and rheumatoid arthritis.
  • Psychiatric disorders: Research indicates its efficacy in improving symptoms of depression and anxiety, providing a new avenue for developing antidepressant medications.
  • Cardiovascular health: The compound shows promise in protecting against heart failure by modulating inflammatory responses and improving cardiac function.
  • Drug delivery systems: Rolipram can be incorporated into nanocarriers for targeted drug delivery, enhancing the efficacy of therapeutic agents in treating various diseases.

Citations