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Catalog Number:
38207
CAS Number:
110078-46-1
Plerixafor
Purity:
≥ 98% (GC)
Synonym(s):
1,4-Bis[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]benzene, AMD 3100
Documents
$126.39 /50MG
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Product Information

Plerixafor is a potent small molecule known for its role as a CXCR4 antagonist, primarily utilized in the field of hematology and oncology. This compound is particularly significant in mobilizing hematopoietic stem cells (HSCs) into peripheral blood, making it invaluable for stem cell transplantation procedures. By inhibiting the interaction between CXCR4 and its ligand, SDF-1, Plerixafor enhances the collection of stem cells for patients undergoing treatments for various blood disorders, including multiple myeloma and non-Hodgkin lymphoma. Its application in combination with G-CSF has shown to significantly increase stem cell yield, thereby improving patient outcomes.

In addition to its therapeutic uses, Plerixafor is also being explored in research settings for its potential in cancer therapy and regenerative medicine. Its unique mechanism of action offers a promising avenue for developing novel treatments targeting CXCR4-related pathways, which are implicated in tumor metastasis and immune response modulation. Researchers and industry professionals can leverage Plerixafor's capabilities to advance their studies and enhance therapeutic strategies in hematology and oncology.

Synonyms
1,4-Bis[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]benzene, AMD 3100
CAS Number
110078-46-1
Purity
≥ 98% (GC)
Molecular Formula
C28H54N8
Molecular Weight
502.8
MDL Number
MFCD05662218
PubChem ID
65015
Melting Point
131 - 135 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
1,4-Bis[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]benzene, AMD 3100
CAS Number
110078-46-1
Purity
≥ 98% (GC)
Molecular Formula
C28H54N8
Molecular Weight
502.8
MDL Number
MFCD05662218
PubChem ID
65015
Melting Point
131 - 135 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Plerixafor is widely utilized in research focused on:

  • Stem Cell Mobilization: It is primarily used to enhance the mobilization of hematopoietic stem cells from the bone marrow into the bloodstream, which is crucial for patients undergoing stem cell transplantation.
  • Cancer Treatment: Plerixafor is applied in oncology to improve the collection of stem cells for patients with certain types of blood cancers, such as multiple myeloma and non-Hodgkin lymphoma, facilitating more effective treatments.
  • Clinical Trials: Researchers employ this compound in clinical studies to evaluate its efficacy in combination with other therapies, helping to advance cancer treatment protocols.
  • HIV Research: It is also explored in HIV research for its ability to block the CXCR4 receptor, which may lead to new therapeutic strategies for managing HIV infection.
  • Pharmaceutical Development: The compound serves as a model in drug development for understanding receptor interactions and designing new drugs targeting similar pathways, enhancing the pharmaceutical industry's innovation.

Citations