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Catalog Number:
38101
CAS Number:
63675-72-9
Nisoldipine
Purity:
≥ 99.5% (Assay, on dry basis)
Synonym(s):
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicacid Isobutyl methyl ester, Isobutyl methyl1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
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Product Information

Nisoldipine is a potent calcium channel blocker primarily used in the management of hypertension and angina pectoris. This compound works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced blood pressure. Its unique structure, characterized by a 2-nitrophenyl group and multiple methyl substitutions, enhances its efficacy and selectivity, making it a preferred choice for patients who require effective blood pressure control with minimal side effects.

In addition to its cardiovascular applications, Nisoldipine has shown promise in research settings, particularly in studies exploring its effects on various vascular conditions. Its ability to selectively target calcium channels can be beneficial in developing treatments for other diseases where calcium regulation is crucial. Researchers and healthcare professionals appreciate Nisoldipine for its consistent performance and favorable pharmacokinetic profile, which allows for once-daily dosing, improving patient compliance.

Synonyms
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicacid Isobutyl methyl ester, Isobutyl methyl1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
CAS Number
63675-72-9
Purity
≥ 99.5% (Assay, on dry basis)
Molecular Formula
C20H24N2O6
Molecular Weight
388.42
MDL Number
MFCD00478055
PubChem ID
4499
Melting Point
148 - 152 °C
Appearance
Yellow crystalline powder
Conditions
Store at 2 - 8 °C
General Information
Synonyms
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicacid Isobutyl methyl ester, Isobutyl methyl1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
CAS Number
63675-72-9
Purity
≥ 99.5% (Assay, on dry basis)
Molecular Formula
C20H24N2O6
Molecular Weight
388.42
MDL Number
MFCD00478055
PubChem ID
4499
Melting Point
148 - 152 °C
Appearance
Yellow crystalline powder
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Nisoldipine is widely utilized in research focused on:

  • Cardiovascular Health: This compound is primarily used as an antihypertensive agent, helping to lower blood pressure in patients with hypertension. It relaxes blood vessels, improving blood flow and reducing the risk of heart-related issues.
  • Pharmaceutical Development: Researchers are exploring its potential in developing new medications for cardiovascular diseases. Its unique properties make it a candidate for formulations aimed at improving patient compliance and efficacy.
  • Clinical Trials: Nisoldipine is often involved in clinical studies to assess its effectiveness and safety in various populations, providing valuable data that can influence treatment guidelines.
  • Combination Therapies: It is frequently studied in combination with other antihypertensive drugs to enhance therapeutic outcomes, allowing for lower doses and reduced side effects compared to monotherapy.
  • Research on Drug Delivery Systems: The compound is being investigated for its role in novel drug delivery methods, which can improve the bioavailability and targeted action of cardiovascular medications.

Citations