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Catalog Number:
38098
CAS Number:
65141-46-0
Nicorandil
Purity:
≥ 98% (HPLC)
Synonym(s):
2-(Pyridine-3-carboxamido)ethyl nitrate, N-[2-(Nitrooxy)ethyl]pyridine-3-carboxamide
Documents
$79.22 /100MG
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Product Information

Nicorandil is a potent vasodilator primarily used in the management of angina pectoris. This compound functions by relaxing blood vessels, thereby improving blood flow and reducing the heart's workload. Its dual mechanism of action—acting as both a nitrate and a potassium channel opener—makes it particularly effective in treating ischemic heart conditions. Researchers and healthcare professionals appreciate Nicorandil for its ability to provide rapid relief from angina symptoms, making it a valuable option in acute care settings. Additionally, its unique properties allow for a sustained effect, which can be beneficial for patients requiring long-term management of their condition.

In the pharmaceutical industry, Nicorandil is recognized for its favorable safety profile compared to traditional nitrates, as it minimizes the risk of tolerance development. This characteristic makes it an attractive choice for clinicians looking to optimize treatment regimens for patients with chronic angina. Furthermore, ongoing research into its potential applications in other cardiovascular diseases highlights its versatility and importance in modern medicine.

Synonyms
2-(Pyridine-3-carboxamido)ethyl nitrate, N-[2-(Nitrooxy)ethyl]pyridine-3-carboxamide
CAS Number
65141-46-0
Purity
≥ 98% (HPLC)
Molecular Formula
C8H9N3O4
Molecular Weight
211.18
MDL Number
MFCD00186520
PubChem ID
47528
Melting Point
88 - 92 °C
Appearance
White to almost white powder to crystal
Conditions
Store at RT
General Information
Synonyms
2-(Pyridine-3-carboxamido)ethyl nitrate, N-[2-(Nitrooxy)ethyl]pyridine-3-carboxamide
CAS Number
65141-46-0
Purity
≥ 98% (HPLC)
Molecular Formula
C8H9N3O4
Molecular Weight
211.18
MDL Number
MFCD00186520
PubChem ID
47528
Melting Point
88 - 92 °C
Appearance
White to almost white powder to crystal
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Nicorandil is widely utilized in research focused on:

  • Cardiovascular Medicine: Primarily used as a vasodilator, it helps in treating angina pectoris by relaxing blood vessels, improving blood flow to the heart.
  • Clinical Trials: Frequently involved in studies assessing its efficacy in managing heart failure and ischemic heart disease, providing valuable data for future treatments.
  • Combination Therapies: Often used in conjunction with other antianginal medications, enhancing therapeutic effects while potentially reducing side effects compared to monotherapy.
  • Research on Drug Delivery Systems: Investigated for its role in developing innovative drug delivery methods, particularly in targeting cardiovascular tissues more effectively.
  • Pharmacological Studies: Serves as a model compound in pharmacokinetic and pharmacodynamic research, helping scientists understand drug interactions and metabolism.

Citations