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Catalog Number:
38092
CAS Number:
21829-25-4
Nifedipine
Grade:
USP
Purity:
98 - 102% (Assay dried basis)
Synonym(s):
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicacid Dimethyl ester
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Product Information

Nifedipine is a potent calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. This compound works by relaxing the smooth muscles of blood vessels, leading to vasodilation and a subsequent reduction in blood pressure. Its unique structure, characterized by a dihydropyridine ring, enhances its efficacy in managing cardiovascular conditions. Nifedipine is also utilized in various formulations, including extended-release tablets, which provide sustained therapeutic effects, making it a preferred choice for long-term management of chronic conditions.

In addition to its cardiovascular applications, Nifedipine has shown promise in treating conditions such as Raynaud's phenomenon and certain types of migraines. Researchers are exploring its potential in other therapeutic areas, given its ability to modulate calcium influx in cells. The compound's favorable safety profile and effectiveness make it a valuable asset in both clinical and research settings, providing healthcare professionals with a reliable option for patient care.

Synonyms
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicacid Dimethyl ester
CAS Number
21829-25-4
Purity
98 - 102% (Assay dried basis)
Grade
USP
Molecular Formula
C17H18N2O6
Molecular Weight
346.34
MDL Number
MFCD00057326
PubChem ID
4485
Melting Point
172 - 175 °C (Lit.)
Appearance
Yellow crystalline powder
Conditions
Store at 2 - 8 °C
General Information
Synonyms
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicacid Dimethyl ester
CAS Number
21829-25-4
Purity
98 - 102% (Assay dried basis)
Grade
USP
Molecular Formula
C17H18N2O6
Molecular Weight
346.34
MDL Number
MFCD00057326
PubChem ID
4485
Melting Point
172 - 175 °C (Lit.)
Appearance
Yellow crystalline powder
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Nifedipine is widely utilized in research focused on

  • Cardiovascular Health: Nifedipine is primarily used to treat hypertension and angina. By relaxing blood vessels, it helps lower blood pressure and improve blood flow, making it essential for patients with heart conditions.
  • Pharmaceutical Development: Researchers often study nifedipine for its pharmacokinetics and pharmacodynamics, aiding in the development of new medications that target similar conditions with improved efficacy and safety profiles.
  • Clinical Trials: Nifedipine is frequently included in clinical trials to evaluate its effectiveness in combination therapies for various cardiovascular diseases, providing insights into better treatment protocols.
  • Research on Drug Interactions: The compound is valuable in studies examining drug interactions, helping to identify potential side effects or enhanced effects when used with other medications.
  • Formulation Science: Nifedipine is also used in formulation research to develop controlled-release delivery systems, improving patient compliance and therapeutic outcomes compared to immediate-release formulations.

Citations