Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
38049
CAS Number:
109581-93-3
Tacrolimus monohydrate
Purity:
≥ 80% (HPLC)
Synonym(s):
FK 506 monohydrate
Hazmat
Documents
$271.01 /10MG
Pack Size Availability Price
Request Bulk Quote
Product Information

Tacrolimus monohydrate is a potent immunosuppressant primarily used in organ transplantation and autoimmune diseases. This compound works by inhibiting T-lymphocyte activation, making it essential in preventing organ rejection in transplant patients. Its unique mechanism of action allows for lower doses compared to other immunosuppressants, reducing the risk of side effects while maintaining efficacy. Tacrolimus monohydrate is also utilized in dermatology for treating severe atopic dermatitis, providing relief from inflammation and itching.

In pharmaceutical formulations, this compound is favored for its high bioavailability and stability, making it suitable for various delivery methods, including topical and oral applications. Researchers are exploring its potential in other therapeutic areas, such as treating inflammatory bowel disease and certain cancers, due to its ability to modulate immune responses. With its proven track record and ongoing research, Tacrolimus monohydrate remains a valuable asset in both clinical and research settings.

Synonyms
FK 506 monohydrate
CAS Number
109581-93-3
Purity
≥ 80% (HPLC)
Molecular Formula
C44H69NO12·H2O
Molecular Weight
822.05
MDL Number
MFCD11045918
PubChem ID
53394824
Melting Point
125 - 129 ?C
Appearance
White to almost white powder to crystal
Conditions
Store at < 0 °C
General Information
Synonyms
FK 506 monohydrate
CAS Number
109581-93-3
Purity
≥ 80% (HPLC)
Molecular Formula
C44H69NO12·H2O
Molecular Weight
822.05
MDL Number
MFCD11045918
PubChem ID
53394824
Melting Point
125 - 129 ?C
Appearance
White to almost white powder to crystal
Conditions
Store at < 0 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Tacrolimus monohydrate is widely utilized in research focused on:

  • Immunosuppressive Therapy: Commonly used in organ transplantation to prevent rejection, it helps maintain the body’s immune response at a manageable level, making it crucial for patients receiving kidney, liver, or heart transplants.
  • Dermatological Treatments: Employed in topical formulations for conditions like eczema and psoriasis, it reduces inflammation and helps in skin healing, offering an alternative to traditional corticosteroids.
  • Research in Autoimmune Disorders: Investigated for its efficacy in treating autoimmune diseases such as lupus and rheumatoid arthritis, providing insights into new therapeutic approaches that can improve patient outcomes.
  • Veterinary Medicine: Used in veterinary practices for immunosuppression in transplant procedures or severe skin conditions in animals, demonstrating its versatility beyond human medicine.
  • Pharmaceutical Development: Serves as a model compound in drug formulation studies, helping researchers understand drug interactions and stability, which is vital for developing new medications.

Citations