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Catalog Number:
38037
CAS Number:
133073-73-1
Methotrexate hydrate
Purity:
≥ 98% (HPLC)
Synonym(s):
(+)-Amethopterin hydrate, 4-Amino-10-methylfolic acid hydrate
Hazmat
Documents
$234.85 /1G
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Product Information

Methotrexate hydrate is a potent antimetabolite and antifolate agent widely utilized in the treatment of various cancers and autoimmune diseases. This compound acts by inhibiting the enzyme dihydrofolate reductase, which is crucial for DNA synthesis and cell replication. Its effectiveness in chemotherapy regimens, particularly for conditions such as leukemia, lymphoma, and breast cancer, makes it a vital component in oncological therapies. Additionally, Methotrexate hydrate is employed in lower doses for the management of rheumatoid arthritis and psoriasis, showcasing its versatility in both oncology and immunology.

Researchers and industry professionals appreciate Methotrexate hydrate for its unique ability to selectively target rapidly dividing cells, which is essential in cancer treatment. Its formulation as a hydrate enhances its solubility and bioavailability, making it easier to administer and absorb in clinical settings. The compound's established efficacy and safety profile, combined with its broad range of applications, position Methotrexate hydrate as a cornerstone in modern therapeutic protocols, providing significant benefits to patients and healthcare providers alike.

Synonyms
(+)-Amethopterin hydrate, 4-Amino-10-methylfolic acid hydrate
CAS Number
133073-73-1
Purity
≥ 98% (HPLC)
Molecular Formula
C20H22N8O5·xH2O
Molecular Weight
454.45
MDL Number
MFCD00150847
PubChem ID
24207740
Melting Point
200 - 205 ?C (Lit.)
Appearance
Light yellow to brown powder to crystal
Optical Rotation
[a]D20 = 18 - 23 ° (C=0.1 in 1mol/L NaOH sol.)(calcd.on anh.substance)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
(+)-Amethopterin hydrate, 4-Amino-10-methylfolic acid hydrate
CAS Number
133073-73-1
Purity
≥ 98% (HPLC)
Molecular Formula
C20H22N8O5·xH2O
Molecular Weight
454.45
MDL Number
MFCD00150847
PubChem ID
24207740
Melting Point
200 - 205 ?C (Lit.)
Appearance
Light yellow to brown powder to crystal
Optical Rotation
[a]D20 = 18 - 23 ° (C=0.1 in 1mol/L NaOH sol.)(calcd.on anh.substance)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Methotrexate hydrate is widely utilized in research focused on:

  • Cancer Treatment: This compound is a cornerstone in chemotherapy regimens for various cancers, including leukemia and lymphoma, by inhibiting cell growth and division.
  • Autoimmune Disorders: It is effective in treating conditions like rheumatoid arthritis and psoriasis, helping to reduce inflammation and immune system activity.
  • Fertility Treatments: Researchers explore its role in fertility, particularly in managing ectopic pregnancies and in certain assisted reproductive technologies.
  • Drug Development: Methotrexate hydrate serves as a model compound in pharmaceutical research, aiding in the development of new drugs targeting similar pathways.
  • Biochemical Studies: It is used in laboratory settings to study folate metabolism and its implications in cellular processes, providing insights into various metabolic disorders.

Citations