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Catalog Number:
38015
CAS Number:
182431-12-5
Lomitapide
Purity:
≥ 98% (HPLC)
Synonym(s):
N-(2,2,2-Trifluoroethyl)-9-[4-[4-[4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido]piperidin-1-yl]butyl]-9H-fluorene-9-carboxamide, BMS-201038
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$228.24 /25MG
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Product Information

Lomitapide is a potent lipid-lowering agent primarily utilized in the management of hypercholesterolemia, particularly in patients with familial hypercholesterolemia. This compound functions by inhibiting the microsomal triglyceride transfer protein (MTP), which plays a crucial role in the assembly and secretion of lipoproteins. By effectively reducing the levels of low-density lipoprotein (LDL) cholesterol, Lomitapide offers significant therapeutic benefits for individuals who are unable to achieve desired cholesterol levels through diet and statin therapy alone.

In addition to its primary application in cardiovascular health, Lomitapide has shown promise in research settings for exploring its effects on lipid metabolism and potential applications in other metabolic disorders. Its unique mechanism of action sets it apart from traditional lipid-lowering therapies, making it an essential option for healthcare providers seeking to optimize treatment strategies for patients with severe cholesterol disorders. Researchers and healthcare professionals can leverage Lomitapide's capabilities to enhance patient outcomes and contribute to advancements in lipid management.

Synonyms
N-(2,2,2-Trifluoroethyl)-9-[4-[4-[4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido]piperidin-1-yl]butyl]-9H-fluorene-9-carboxamide, BMS-201038
CAS Number
182431-12-5
Purity
≥ 98% (HPLC)
Molecular Formula
C39H37F6N3O2
Molecular Weight
693.73
MDL Number
MFCD16620494
PubChem ID
9853053
Melting Point
141 - 143 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
N-(2,2,2-Trifluoroethyl)-9-[4-[4-[4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido]piperidin-1-yl]butyl]-9H-fluorene-9-carboxamide, BMS-201038
CAS Number
182431-12-5
Purity
≥ 98% (HPLC)
Molecular Formula
C39H37F6N3O2
Molecular Weight
693.73
MDL Number
MFCD16620494
PubChem ID
9853053
Melting Point
141 - 143 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Lomitapide is widely utilized in research focused on

  • Hyperlipidemia Treatment: This compound is primarily used in the treatment of familial hypercholesterolemia, helping patients manage high cholesterol levels effectively.
  • Cardiovascular Health: By lowering LDL cholesterol, it plays a crucial role in reducing the risk of cardiovascular diseases, making it vital for heart health management.
  • Pharmaceutical Development: Researchers are exploring Lomitapide in developing new therapies for lipid disorders, enhancing treatment options for patients with metabolic syndromes.
  • Clinical Research: It serves as a key subject in clinical trials aimed at understanding lipid metabolism and the efficacy of cholesterol-lowering drugs.
  • Personalized Medicine: The compound's unique mechanism allows for tailored treatment plans, addressing individual patient needs in lipid management.

Citations