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Catalog Number:
37992
CAS Number:
79794-75-5
Loratadine
Grade:
Meets USP specifications
Purity:
98.5 - 101.0% (HPLC)
Synonym(s):
4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylicacid ethyl ester
Documents
$54.08 /100MG
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Product Information

Loratadine is a widely recognized antihistamine known for its effectiveness in alleviating allergy symptoms such as sneezing, runny nose, and itchy eyes. This compound operates by selectively blocking peripheral histamine H1 receptors, making it a preferred choice for both seasonal and perennial allergic rhinitis. Its long-lasting effects allow for once-daily dosing, providing convenience for users. Loratadine is also utilized in various formulations, including tablets, syrups, and dissolvable strips, catering to diverse patient needs.

In addition to its primary use in allergy relief, Loratadine has shown potential in managing chronic urticaria (hives) and other allergic skin conditions. Its non-sedating properties make it suitable for individuals who require relief without the drowsiness associated with first-generation antihistamines. Researchers and healthcare professionals appreciate Loratadine for its favorable safety profile and minimal drug interactions, making it a reliable option in allergy management.

Synonyms
4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylicacid ethyl ester
CAS Number
79794-75-5
Purity
98.5 - 101.0% (HPLC)
Grade
Meets USP specifications
Molecular Formula
C22H23ClN2O2
Molecular Weight
382.89
MDL Number
MFCD00672869
PubChem ID
3957
Melting Point
135 - 139 °C
Appearance
White to off-white powder
Conditions
Store at 2 - 8 °C
General Information
Synonyms
4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylicacid ethyl ester
CAS Number
79794-75-5
Purity
98.5 - 101.0% (HPLC)
Grade
Meets USP specifications
Molecular Formula
C22H23ClN2O2
Molecular Weight
382.89
MDL Number
MFCD00672869
PubChem ID
3957
Melting Point
135 - 139 °C
Appearance
White to off-white powder
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Loratadine is widely utilized in research focused on:

  • Allergy Relief: Commonly used as an antihistamine, it effectively alleviates symptoms of allergies, such as sneezing and runny nose, making it a staple in over-the-counter allergy medications.
  • Seasonal Allergic Rhinitis: It is particularly beneficial for individuals suffering from hay fever, providing long-lasting relief without causing significant drowsiness, which is a common side effect of many other antihistamines.
  • Chronic Urticaria Treatment: Loratadine is effective in managing chronic hives, helping to reduce itching and the appearance of welts, thus improving the quality of life for patients.
  • Research in Pharmacology: It serves as a model compound in pharmacological studies to understand the mechanisms of antihistamines and their effects on the human body, aiding in the development of new medications.
  • Formulation in Pediatric Medicine: Its safety profile makes it suitable for use in children, leading to its inclusion in pediatric formulations for treating allergic conditions.

Citations