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Catalog Number:
37991
CAS Number:
83915-83-7
Lisinopril dihydrate
Purity:
≥ 98% (Assay by Titration)
Synonym(s):
1-[Na-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl]-L-prolinedihydrate
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Product Information

Lisinopril dihydrate is a potent angiotensin-converting enzyme (ACE) inhibitor widely utilized in the management of hypertension and heart failure. This compound is recognized for its ability to lower blood pressure by inhibiting the conversion of angiotensin I to angiotensin II, a peptide that constricts blood vessels. Its efficacy in reducing cardiovascular events makes it a staple in cardiovascular therapy. Lisinopril dihydrate is also employed in the treatment of diabetic nephropathy, showcasing its versatility in managing conditions related to kidney function.

Researchers and healthcare professionals appreciate Lisinopril dihydrate for its favorable pharmacokinetic profile, which allows for once-daily dosing, enhancing patient compliance. Its dihydrate form ensures stability and solubility, making it suitable for various formulations, including tablets and injectables. The compound's unique mechanism of action and its role in improving patient outcomes in chronic conditions underscore its significance in modern medicine.

Synonyms
1-[Na-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl]-L-prolinedihydrate
CAS Number
83915-83-7
Purity
≥ 98% (Assay by Titration)
Molecular Formula
C21H31O5N3·2H2O
Molecular Weight
441.53
MDL Number
MFCD01698825
PubChem ID
22990485
Melting Point
147 - 149 °C
Appearance
White to almost white powder to crystal
Optical Rotation
[a]20D = -42 to -48 ° (C=1, 0.25 mol/L Zinc Acetate buffer sol.) (calcd.on anh.substance)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
1-[Na-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl]-L-prolinedihydrate
CAS Number
83915-83-7
Purity
≥ 98% (Assay by Titration)
Molecular Formula
C21H31O5N3·2H2O
Molecular Weight
441.53
MDL Number
MFCD01698825
PubChem ID
22990485
Melting Point
147 - 149 °C
Appearance
White to almost white powder to crystal
Optical Rotation
[a]20D = -42 to -48 ° (C=1, 0.25 mol/L Zinc Acetate buffer sol.) (calcd.on anh.substance)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Lisinopril dihydrate is widely utilized in research focused on:

  • Hypertension Treatment: It is primarily used as an antihypertensive medication, helping to lower blood pressure in patients with hypertension, which is crucial for reducing the risk of heart disease and stroke.
  • Heart Failure Management: This compound is effective in treating heart failure, improving survival rates and quality of life for patients by reducing the workload on the heart.
  • Diabetic Kidney Disease: Lisinopril dihydrate is beneficial in protecting kidney function in diabetic patients, making it a vital component in managing diabetic nephropathy.
  • Research in Cardiovascular Health: It is widely studied in clinical trials to understand its effects on cardiovascular health, providing valuable data that can lead to improved treatment protocols.
  • Combination Therapies: This compound is often used in combination with other medications, enhancing therapeutic outcomes for various cardiovascular conditions while minimizing side effects compared to other treatments.

Citations