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Catalog Number:
37883
CAS Number:
72509-76-3
Felodipine
Grade:
USP
Purity:
98 - 101% (Assay, on dried basis)
Synonym(s):
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid Ethyl methyl ester, Ethyl methyl 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Hazmat
Documents
$18.53 /1G
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Product Information

Felodipine is a potent calcium channel blocker primarily used in the management of hypertension and angina. This dihydropyridine derivative works by inhibiting calcium influx into vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced blood pressure. Its unique structure, featuring a dichlorophenyl group, enhances its selectivity and efficacy, making it a preferred choice in clinical settings. Felodipine is often formulated in extended-release preparations, allowing for once-daily dosing, which improves patient compliance and therapeutic outcomes.

In addition to its cardiovascular applications, Felodipine is also being explored for its potential benefits in treating other conditions, such as Raynaud's phenomenon and certain types of heart failure. Researchers appreciate its favorable pharmacokinetic profile, which includes a long half-life and minimal side effects compared to other antihypertensives. This compound's ability to provide sustained blood pressure control while minimizing adverse reactions positions it as a valuable option for healthcare professionals seeking effective treatment strategies.

Synonyms
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid Ethyl methyl ester, Ethyl methyl 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
CAS Number
72509-76-3
Purity
98 - 101% (Assay, on dried basis)
Grade
USP
Molecular Formula
C18H19Cl2NO4
Molecular Weight
384.25
MDL Number
MFCD00868316
PubChem ID
3333
Melting Point
142 - 146 ?C
Appearance
White to pale yellow crystalline powder
Conditions
Store at RT
General Information
Synonyms
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid Ethyl methyl ester, Ethyl methyl 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
CAS Number
72509-76-3
Purity
98 - 101% (Assay, on dried basis)
Grade
USP
Molecular Formula
C18H19Cl2NO4
Molecular Weight
384.25
MDL Number
MFCD00868316
PubChem ID
3333
Melting Point
142 - 146 ?C
Appearance
White to pale yellow crystalline powder
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Felodipine is widely utilized in research focused on:

  • Cardiovascular Health: Primarily used as an antihypertensive agent, it helps manage high blood pressure, reducing the risk of heart-related complications.
  • Pharmaceutical Development: Employed in the formulation of various medications, it serves as a model compound for studying drug absorption and metabolism.
  • Clinical Trials: Frequently involved in clinical studies aimed at evaluating the efficacy of new treatments for hypertension and related cardiovascular conditions.
  • Research on Drug Interactions: Useful in studies assessing how different substances interact with antihypertensive medications, aiding in safer prescribing practices.
  • Patient Compliance Studies: Investigated for its role in improving patient adherence to treatment regimens due to its extended-release formulations, which require less frequent dosing.

Citations