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Catalog Number:
37842
CAS Number:
77-67-8
Ethosuximide
Purity:
≥ 98% (Assay by titration, GC)
Synonym(s):
2-Ethyl-2-methylsuccinimide
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Product Information

Ethosuximide is a well-established anticonvulsant medication primarily used in the treatment of absence seizures, particularly in pediatric patients. This compound operates by inhibiting T-type calcium channels in the thalamic neurons, effectively reducing the frequency and severity of seizures. Its unique mechanism of action makes it a preferred choice over other anticonvulsants for managing this specific type of epilepsy, as it minimizes side effects while maximizing therapeutic efficacy. Ethosuximide is also being explored for potential applications in other neurological disorders, showcasing its versatility in clinical settings.

In addition to its primary use in epilepsy management, Ethosuximide has demonstrated promise in research settings, particularly in studies investigating the modulation of neuronal excitability and synaptic transmission. Its favorable pharmacokinetic profile, including good oral bioavailability and a relatively long half-life, enhances its practicality for both patients and healthcare providers. Researchers and clinicians appreciate Ethosuximide for its targeted action and minimal adverse effects, making it an essential compound in the field of neurology.

Synonyms
2-Ethyl-2-methylsuccinimide
CAS Number
77-67-8
Purity
≥ 98% (Assay by titration, GC)
Molecular Formula
C7H11NO2
Molecular Weight
141.17
MDL Number
MFCD00072123
PubChem ID
3291
Melting Point
48 - 52 °C
Appearance
White to almost white powder to crystal
Boiling Point
150 °C / 12 mmHg
Conditions
Store at 2 - 8 °C
General Information
Synonyms
2-Ethyl-2-methylsuccinimide
CAS Number
77-67-8
Purity
≥ 98% (Assay by titration, GC)
Molecular Formula
C7H11NO2
Molecular Weight
141.17
MDL Number
MFCD00072123
PubChem ID
3291
Melting Point
48 - 52 °C
Appearance
White to almost white powder to crystal
Boiling Point
150 °C / 12 mmHg
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Ethosuximide is widely utilized in research focused on:

  • Epilepsy Treatment: Primarily used as an anticonvulsant medication for absence seizures, providing effective seizure control with fewer side effects compared to other treatments.
  • Neuroscience Research: Serves as a tool in studies investigating the mechanisms of epilepsy and neuronal excitability, helping researchers understand seizure dynamics.
  • Pharmacological Studies: Used in drug development research to explore new formulations and combinations that enhance efficacy and reduce adverse effects.
  • Pediatric Medicine: Commonly prescribed for children with absence seizures, offering a safer profile which is crucial for this sensitive population.
  • Comparative Effectiveness Research: Assists in evaluating the effectiveness of various anticonvulsants, guiding clinicians in personalized treatment plans.

Citations