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Catalog Number:
37791
CAS Number:
33286-22-5
(+)-cis-Diltiazem hydrochloride
Purity:
98 - 102% (Assay)
Synonym(s):
(2S,3S)-(+)-3-Acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-onehydrochloride
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Product Information

(+)-cis-Diltiazem hydrochloride is a potent calcium channel blocker widely utilized in the treatment of cardiovascular conditions such as hypertension and angina. This compound functions by inhibiting calcium influx into cardiac and smooth muscle cells, leading to vasodilation and reduced heart workload. Its unique structure allows for effective modulation of heart rate and blood pressure, making it a valuable asset in clinical settings. Researchers and healthcare professionals appreciate its dual action on both the heart and blood vessels, which enhances its therapeutic profile compared to other calcium channel blockers.

In addition to its medical applications, (+)-cis-Diltiazem hydrochloride is also explored in pharmaceutical research for developing novel formulations and drug delivery systems. Its favorable pharmacokinetic properties and compatibility with various excipients make it an ideal candidate for innovative therapeutic strategies. This compound's versatility and effectiveness in managing cardiovascular diseases underscore its significance in both clinical and research environments, providing a reliable option for healthcare professionals seeking effective treatment solutions.

Synonyms
(2S,3S)-(+)-3-Acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-onehydrochloride
CAS Number
33286-22-5
Purity
98 - 102% (Assay)
Molecular Formula
C22H26N2O4S·HCl
Molecular Weight
450.98
MDL Number
MFCD00069252
PubChem ID
214464
Melting Point
210 - 215 °C
Appearance
White crystalline powder
Optical Rotation
[a]D20 = 110 - 116 ° (C=1 in Water)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
(2S,3S)-(+)-3-Acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-onehydrochloride
CAS Number
33286-22-5
Purity
98 - 102% (Assay)
Molecular Formula
C22H26N2O4S·HCl
Molecular Weight
450.98
MDL Number
MFCD00069252
PubChem ID
214464
Melting Point
210 - 215 °C
Appearance
White crystalline powder
Optical Rotation
[a]D20 = 110 - 116 ° (C=1 in Water)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

(+)-cis-Diltiazem hydrochloride is widely utilized in research focused on

  • Cardiovascular Health: This compound is primarily used in the treatment of hypertension and angina. It helps relax blood vessels, improving blood flow and reducing heart workload, making it essential in cardiology.
  • Pharmaceutical Development: Researchers often use it as a reference compound in drug formulation studies due to its established efficacy and safety profile, aiding in the development of new cardiovascular medications.
  • Clinical Trials: It serves as a standard in clinical trials assessing new treatments for heart diseases, providing a benchmark for efficacy and safety comparisons.
  • Research on Drug Interactions: The compound is studied for its interactions with other medications, helping to understand polypharmacy effects, particularly in elderly patients with multiple health issues.
  • Educational Purposes: It is frequently used in pharmacology courses to teach students about calcium channel blockers, their mechanisms of action, and their therapeutic applications.

Citations