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Catalog Number:
37722
CAS Number:
132203-70-4
Cilnidipine
Purity:
≥ 99% (Assay, on dry basis)
Synonym(s):
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl ester, 2-Methoxyethyl (2E)-3-phenyl-2-propenyl1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
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Product Information

Cilnidipine is a potent calcium channel blocker that has garnered attention for its dual action on L-type and N-type calcium channels, making it particularly effective in managing hypertension and angina. This unique mechanism not only helps in reducing blood pressure but also offers neuroprotective benefits, which can be advantageous in treating conditions like chronic pain and certain neurological disorders. Cilnidipine's ability to improve blood flow and reduce vascular resistance makes it a valuable compound in cardiovascular research and pharmaceutical applications.

In addition to its therapeutic uses, Cilnidipine has shown promise in various clinical studies, demonstrating a favorable safety profile and efficacy compared to traditional calcium channel blockers. Its application in combination therapies further enhances its utility, providing a comprehensive approach to managing cardiovascular diseases. Researchers and healthcare professionals can leverage Cilnidipine's unique properties to develop innovative treatment strategies that address complex patient needs effectively.

Synonyms
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl ester, 2-Methoxyethyl (2E)-3-phenyl-2-propenyl1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
CAS Number
132203-70-4
Purity
≥ 99% (Assay, on dry basis)
Molecular Formula
C27H28N2O7
Molecular Weight
492.53
MDL Number
MFCD00865853
PubChem ID
2752
Melting Point
108 - 112 °C
Appearance
Light yellow powder
Conditions
Store at 2 - 8 °C
General Information
Synonyms
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl ester, 2-Methoxyethyl (2E)-3-phenyl-2-propenyl1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
CAS Number
132203-70-4
Purity
≥ 99% (Assay, on dry basis)
Molecular Formula
C27H28N2O7
Molecular Weight
492.53
MDL Number
MFCD00865853
PubChem ID
2752
Melting Point
108 - 112 °C
Appearance
Light yellow powder
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Cilnidipine is widely utilized in research focused on:

  • Hypertension Treatment: This compound is primarily used in the formulation of antihypertensive medications. It effectively lowers blood pressure by relaxing blood vessels, making it a valuable option for patients with high blood pressure.
  • Cardiovascular Health: Cilnidipine helps in improving overall cardiovascular health by preventing complications associated with hypertension, such as heart attacks and strokes. Its dual action on calcium channels provides a unique advantage over other antihypertensives.
  • Diabetes Management: Research indicates that cilnidipine may have beneficial effects on insulin sensitivity, making it a potential candidate for managing blood pressure in diabetic patients, who often face challenges with hypertension.
  • Neuroprotective Effects: Emerging studies suggest that cilnidipine may offer neuroprotective benefits, potentially aiding in the treatment of neurodegenerative diseases by improving cerebral blood flow.
  • Combination Therapy: Its compatibility with other antihypertensive agents allows for effective combination therapies, providing tailored treatment options for patients who require more than one medication to manage their blood pressure.

Citations