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Catalog Number:
37601
CAS Number:
2016-88-8
Amiloride hydrochloride
Purity:
≥ 98.5% (HPLC)
Synonym(s):
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride, 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride
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$172.36 /5G
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Product Information

Amiloride hydrochloride is a potent diuretic agent widely utilized in the treatment of hypertension and heart failure. This compound functions primarily as a potassium-sparing diuretic, effectively promoting the excretion of sodium while retaining potassium, which is crucial for maintaining electrolyte balance in patients. Its unique mechanism of action makes it particularly valuable in combination therapies, enhancing the efficacy of other antihypertensive medications while minimizing the risk of hypokalemia.

In addition to its cardiovascular applications, Amiloride hydrochloride has shown promise in research settings, particularly in studies related to cystic fibrosis and certain renal disorders. Its ability to inhibit sodium channels in epithelial tissues opens avenues for further exploration in various therapeutic areas. With its favorable safety profile and effectiveness, Amiloride hydrochloride remains a critical compound for healthcare professionals seeking reliable treatment options for managing fluid retention and hypertension.

Synonyms
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride, 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride
CAS Number
2016-88-8
Purity
≥ 98.5% (HPLC)
Molecular Formula
C6H8ClN7O·HCl
Molecular Weight
266.09
MDL Number
MFCD00058197
PubChem ID
16230
Appearance
Light yellow powder
Conditions
Store at 0-8 °C
General Information
Synonyms
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride, 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride
CAS Number
2016-88-8
Purity
≥ 98.5% (HPLC)
Molecular Formula
C6H8ClN7O·HCl
Molecular Weight
266.09
MDL Number
MFCD00058197
PubChem ID
16230
Appearance
Light yellow powder
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Amiloride hydrochloride is widely utilized in research focused on

  • Hypertension Management: This compound is primarily used as a potassium-sparing diuretic in the treatment of high blood pressure, helping to reduce the risk of heart disease.
  • Heart Failure Treatment: It aids in managing heart failure by preventing excessive potassium loss, which is crucial for maintaining heart function.
  • Kidney Function Studies: Researchers often use amiloride hydrochloride to study renal physiology and the mechanisms of sodium transport in the kidneys, providing insights into kidney diseases.
  • Diabetes Research: The compound has been investigated for its potential role in improving insulin sensitivity and glucose metabolism, making it relevant in diabetes studies.
  • Pharmaceutical Development: Its unique properties make it a valuable candidate in developing new medications targeting electrolyte balance and fluid retention issues.

Citations