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Catalog Number:
37588
CAS Number:
344423-98-9
Atorvastatin calcium salt trihydrate
Purity:
≥ 98% (HPLC)
Synonym(s):
Atorvastatin hemicalcium salt sesquihydrate
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Product Information

Atorvastatin calcium salt trihydrate is a potent lipid-lowering agent widely recognized for its role in managing cholesterol levels. This compound is primarily utilized in the pharmaceutical industry for the treatment of hyperlipidemia and the prevention of cardiovascular diseases. Its mechanism of action involves inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol synthesis, thereby effectively reducing low-density lipoprotein (LDL) cholesterol and triglycerides while increasing high-density lipoprotein (HDL) cholesterol. Researchers and healthcare professionals value Atorvastatin for its efficacy and safety profile, making it a preferred choice in clinical settings.

In addition to its primary use in cholesterol management, Atorvastatin calcium salt trihydrate has shown potential in various therapeutic areas, including anti-inflammatory and neuroprotective effects. Its versatility extends to research applications, where it is studied for its impact on metabolic syndrome and its potential benefits in patients with diabetes. The compound's stability and solubility characteristics enhance its formulation possibilities, making it suitable for various delivery methods, including tablets and oral solutions. This adaptability, combined with its proven effectiveness, positions Atorvastatin calcium salt trihydrate as a valuable asset in both clinical and research environments.

Synonyms
Atorvastatin hemicalcium salt sesquihydrate
CAS Number
344423-98-9
Purity
≥ 98% (HPLC)
Molecular Formula
C66H68CaF2N4O10·3H2O
Molecular Weight
1209.41
MDL Number
MFCD09752074
PubChem ID
18183309
Appearance
White to almost white powder to crystal
Optical Rotation
[a]20D = -7 to -10 ° (C=1 in DMSO) (calcd.on anh.substance)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
Atorvastatin hemicalcium salt sesquihydrate
CAS Number
344423-98-9
Purity
≥ 98% (HPLC)
Molecular Formula
C66H68CaF2N4O10·3H2O
Molecular Weight
1209.41
MDL Number
MFCD09752074
PubChem ID
18183309
Appearance
White to almost white powder to crystal
Optical Rotation
[a]20D = -7 to -10 ° (C=1 in DMSO) (calcd.on anh.substance)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Atorvastatin calcium salt trihydrate is widely utilized in research focused on:

  • Cardiovascular Health: This compound is primarily known for its role in lowering cholesterol levels, making it essential in the development of medications aimed at reducing the risk of heart disease.
  • Pharmaceutical Development: Researchers use atorvastatin in drug formulation studies to enhance the efficacy of cholesterol-lowering therapies, providing insights into dosage optimization and patient adherence.
  • Clinical Trials: It is frequently involved in clinical studies assessing the long-term effects of statin therapy on cardiovascular outcomes, helping to shape treatment guidelines.
  • Combination Therapies: Atorvastatin is often explored in combination with other medications to evaluate synergistic effects, particularly in patients with multiple risk factors for cardiovascular disease.
  • Biochemical Research: The compound serves as a valuable tool in studies investigating lipid metabolism and the mechanisms of action of statins, contributing to a deeper understanding of cardiovascular biology.

Citations