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Catalog Number:
37584
CAS Number:
123524-52-7
Azelnidipine
Purity:
≥ 98% (Assay by titration, HPLC)
Synonym(s):
2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid 3-[1-(Diphenylmethyl)-3-azetidinyl] 5-isopropyl ester, 3-[1-(Diphenylmethyl)-3-azetidinyl] 5-isopropyl2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
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Product Information

Azelnidipine is a potent calcium channel blocker that is primarily utilized in the management of hypertension and related cardiovascular conditions. This compound works by inhibiting calcium influx into vascular smooth muscle and cardiac muscle, leading to vasodilation and a subsequent reduction in blood pressure. Its unique structure, featuring a benzhydrylazetidine moiety, enhances its selectivity and efficacy, making it a preferred choice for patients requiring effective blood pressure control with minimal side effects.

In addition to its primary use in treating hypertension, Azelnidipine has shown promise in research settings for its potential neuroprotective effects, which could be beneficial in conditions such as stroke and neurodegenerative diseases. The compound's favorable pharmacokinetic profile allows for once-daily dosing, improving patient compliance. With its dual action of lowering blood pressure and potentially offering neuroprotection, Azelnidipine stands out as a versatile agent in both clinical and research applications.

Synonyms
2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid 3-[1-(Diphenylmethyl)-3-azetidinyl] 5-isopropyl ester, 3-[1-(Diphenylmethyl)-3-azetidinyl] 5-isopropyl2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
CAS Number
123524-52-7
Purity
≥ 98% (Assay by titration, HPLC)
Molecular Formula
C33H34N4O6
Molecular Weight
582.66
MDL Number
MFCD00865803
PubChem ID
65948
Appearance
Light orange to yellow to green powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid 3-[1-(Diphenylmethyl)-3-azetidinyl] 5-isopropyl ester, 3-[1-(Diphenylmethyl)-3-azetidinyl] 5-isopropyl2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
CAS Number
123524-52-7
Purity
≥ 98% (Assay by titration, HPLC)
Molecular Formula
C33H34N4O6
Molecular Weight
582.66
MDL Number
MFCD00865803
PubChem ID
65948
Appearance
Light orange to yellow to green powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Azelnidipine is widely utilized in research focused on:

  • Hypertension Treatment: This compound is primarily used in the pharmaceutical industry for the management of high blood pressure, providing an effective option for patients who require long-term treatment.
  • Cardiovascular Health: It plays a crucial role in improving cardiovascular outcomes by reducing the risk of heart-related complications, making it a valuable choice for cardiologists.
  • Research on Calcium Channel Blockers: Azelnidipine is studied for its mechanism as a calcium channel blocker, which helps researchers understand its effects on vascular smooth muscle and cardiac function.
  • Combination Therapies: It is often used in combination with other antihypertensive agents, enhancing treatment efficacy and allowing for personalized medicine approaches in managing hypertension.
  • Clinical Trials: The compound is frequently involved in clinical trials aimed at exploring new therapeutic strategies for hypertension and related disorders, contributing to advancements in medical research.

Citations