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Catalog Number:
37341
CAS Number:
43112-38-5
3-(Trimethylsilyl)-2-oxazolidinone
Purity:
≥ 98% (GC)
Synonym(s):
2-Oxo-3-(trimethylsilyl)-1,3-oxazolidine, TMSO
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Product Information

3-(Trimethylsilyl)-2-oxazolidinone is a versatile chemical compound widely utilized in organic synthesis and pharmaceutical research. This compound, also known as TMS-oxazolidinone, serves as a valuable protecting group for amines and carboxylic acids, facilitating the selective functionalization of complex molecules. Its unique trimethylsilyl group enhances stability and solubility, making it an ideal choice for reactions under various conditions. Researchers appreciate its ability to streamline synthetic pathways, particularly in the development of biologically active compounds and natural products.

In addition to its role in organic synthesis, 3-(Trimethylsilyl)-2-oxazolidinone has applications in the preparation of chiral intermediates and the synthesis of heterocyclic compounds. Its effectiveness in stabilizing reactive intermediates allows for improved yields and selectivity in chemical reactions. This compound is particularly beneficial for chemists looking to enhance the efficiency of their synthetic processes while minimizing by-products. With its broad applicability and advantageous properties, 3-(Trimethylsilyl)-2-oxazolidinone is an essential tool for researchers and industry professionals alike.

Synonyms
2-Oxo-3-(trimethylsilyl)-1,3-oxazolidine, TMSO
CAS Number
43112-38-5
Purity
≥ 98% (GC)
Molecular Formula
C6H13NO2Si
Molecular Weight
159.26
MDL Number
MFCD00010197
PubChem ID
123514
Density
1.046
Appearance
Colorless to dark Yellow or green liquid
Boiling Point
99 - 100 °C / 6 mmHg
Refractive Index
1.455
Conditions
Store at RT
General Information
Synonyms
2-Oxo-3-(trimethylsilyl)-1,3-oxazolidine, TMSO
CAS Number
43112-38-5
Purity
≥ 98% (GC)
Molecular Formula
C6H13NO2Si
Molecular Weight
159.26
MDL Number
MFCD00010197
PubChem ID
123514
Density
1.046
Appearance
Colorless to dark Yellow or green liquid
Boiling Point
99 - 100 °C / 6 mmHg
Refractive Index
1.455
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

3-(Trimethylsilyl)-2-oxazolidinone is widely utilized in research focused on:

  • Synthetic Organic Chemistry: This compound serves as a versatile protecting group for amines and alcohols, facilitating the synthesis of complex organic molecules while preventing unwanted reactions.
  • Pharmaceutical Development: It is employed in the development of pharmaceutical intermediates, enhancing the stability and solubility of drug candidates, which is crucial for effective formulation.
  • Polymer Chemistry: This chemical is used in the synthesis of functionalized polymers, contributing to the development of materials with tailored properties for specific applications, such as drug delivery systems.
  • Analytical Chemistry: It acts as a derivatizing agent in gas chromatography, improving the detection and quantification of various compounds, which is essential for quality control in laboratories.
  • Material Science: The compound is utilized in the production of siloxane-based materials, which exhibit unique thermal and mechanical properties, making them suitable for high-performance applications.

Citations