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Catalog Number:
35057
PC DBCO-NHS ester
Purity:
≥ 95% (HPLC)
Synonym(s):
Photocleavable dibenzocyclooctyne-NHS ester
Documents
$116.10 /5MG
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Product Information

The PC DBCO-NHS ester is a versatile and highly functional chemical compound widely utilized in bioconjugation and drug delivery applications. This compound features a unique DBCO (dibenzocyclooctyne) moiety that allows for efficient and selective reactions with azide-containing biomolecules, making it an invaluable tool for researchers in the fields of biochemistry and molecular biology. Its NHS (N-hydroxysuccinimide) ester functionality further enhances its reactivity, facilitating the formation of stable amide bonds with primary amines. This property is particularly beneficial in the development of targeted therapeutics and diagnostic agents, where precise conjugation is crucial.

In practical applications, PC DBCO-NHS ester has been employed in the synthesis of antibody-drug conjugates (ADCs), enabling the targeted delivery of cytotoxic agents to cancer cells while minimizing off-target effects. Additionally, it is used in the preparation of fluorescent probes for imaging studies, allowing researchers to visualize cellular processes with high specificity. The compound's ease of use and compatibility with various biological systems make it a preferred choice for professionals seeking reliable and efficient conjugation strategies.

Synonyms
Photocleavable dibenzocyclooctyne-NHS ester
Purity
≥ 95% (HPLC)
Molecular Formula
C47H55N5O16
Molecular Weight
945.96
Appearance
Yellow amorphous solid
Conditions
Store at -10 °C, desiccate and shipped at ambient temperature
General Information
Synonyms
Photocleavable dibenzocyclooctyne-NHS ester
Purity
≥ 95% (HPLC)
Molecular Formula
C47H55N5O16
Molecular Weight
945.96
Appearance
Yellow amorphous solid
Conditions
Store at -10 °C, desiccate and shipped at ambient temperature
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

PC DBCO-NHS ester is widely utilized in research focused on:

  • Bioconjugation: This compound is essential for attaching biomolecules like proteins or antibodies to surfaces or other molecules, enhancing the development of targeted drug delivery systems.
  • Fluorescent Labeling: It serves as a linker for fluorescent dyes, allowing researchers to visualize cellular processes in real-time, which is crucial in fields like cell biology and cancer research.
  • Diagnostics: The compound is used in the creation of diagnostic assays, improving the sensitivity and specificity of tests for diseases, particularly in the medical diagnostics industry.
  • Material Science: It aids in the functionalization of materials, enabling the development of smart materials that respond to environmental changes, which is beneficial in various engineering applications.
  • Vaccine Development: PC DBCO-NHS ester plays a role in the formulation of vaccines by facilitating the conjugation of antigens to carriers, enhancing immune responses and vaccine efficacy.

Citations