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Catalog Number:
35051
CAS Number:
1427004-19-0
DBCO-PEG4-NHS ester
Purity:
≥ 95% (NMR)
Synonym(s):
Dibenzocyclooctyne-PEG4-NHS ester
Documents
$140.00 /5MG
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Product Information

DBCO-PEG4-NHS ester is a versatile and highly functional compound widely utilized in bioconjugation and drug delivery applications. This compound features a unique combination of a DBCO (dibenzocyclooctyne) moiety and a PEG4 (polyethylene glycol) linker, which enhances solubility and biocompatibility. The NHS (N-hydroxysuccinimide) ester functionality allows for efficient coupling to amine-containing biomolecules, making it an ideal choice for researchers looking to create stable conjugates for therapeutic and diagnostic purposes.

In the field of biochemistry, DBCO-PEG4-NHS ester is particularly valuable for labeling proteins, antibodies, and other biomolecules, facilitating the development of targeted drug delivery systems and imaging agents. Its ability to form stable covalent bonds with various substrates enables the creation of complex biomolecular constructs, which can significantly improve the efficacy of therapeutic agents. Additionally, the PEG component contributes to reduced immunogenicity and enhanced circulation time in vivo, making this compound a preferred choice for innovative drug formulation strategies.

Synonyms
Dibenzocyclooctyne-PEG4-NHS ester
CAS Number
1427004-19-0
Purity
≥ 95% (NMR)
Molecular Formula
C34H39N3O10
Molecular Weight
649.68
MDL Number
MFCD26793797
PubChem ID
77078155
Appearance
Yellow oil to yellowish liquid
Conditions
Store at -10 °C, desiccate and shipped at ambient temperature
General Information
Synonyms
Dibenzocyclooctyne-PEG4-NHS ester
CAS Number
1427004-19-0
Purity
≥ 95% (NMR)
Molecular Formula
C34H39N3O10
Molecular Weight
649.68
MDL Number
MFCD26793797
PubChem ID
77078155
Appearance
Yellow oil to yellowish liquid
Conditions
Store at -10 °C, desiccate and shipped at ambient temperature
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

DBCO-PEG4-NHS ester is widely utilized in research focused on:

  • Bioconjugation: This compound is essential for attaching biomolecules, such as proteins or antibodies, to surfaces or other molecules, enhancing the development of targeted therapies and diagnostics.
  • Drug Delivery Systems: Its ability to form stable linkages makes it ideal for creating advanced drug delivery systems, allowing for controlled release of therapeutics in specific tissues, improving treatment efficacy.
  • Fluorescent Labeling: Researchers use DBCO-PEG4-NHS ester to label biomolecules with fluorescent tags, facilitating real-time tracking of biological processes in live cells, which is crucial for understanding cellular functions.
  • Surface Modification: This ester is employed to modify surfaces of materials in biosensors, enhancing their sensitivity and specificity for detecting biomolecules, which is vital in medical diagnostics.
  • Polymer Chemistry: In the field of polymer science, it serves as a building block for creating functionalized polymers, leading to innovative materials with unique properties for various industrial applications.

Citations