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Catalog Number:
33603
CAS Number:
1217811-90-9
Fmoc-4-chloro-2-fluoro-L-phenylalanine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-L-Phe(4-Cl,2-F)-OH, (S)-Fmoc-2-amino-4-chloro-2-fluorophenylpropionic acid, Fmoc-Phe(4-Cl,2-F)-OH
Documents
$35.00 /100MG
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Product Information

Fmoc-4-chloro-2-fluoro-L-phenylalanine is a valuable building block in peptide synthesis, particularly in the development of pharmaceuticals and biologically active compounds. This compound features a unique combination of a fluorinated aromatic ring and a protective Fmoc (9-fluorenylmethoxycarbonyl) group, making it an ideal choice for researchers focused on creating complex peptides with enhanced stability and bioactivity. Its ability to introduce halogen atoms into peptide sequences can significantly influence the pharmacological properties of the resulting compounds, offering potential advantages in drug design and development.

In practical applications, Fmoc-4-chloro-2-fluoro-L-phenylalanine is widely utilized in combinatorial chemistry and high-throughput screening, where the need for diverse and functional peptide libraries is paramount. Its compatibility with solid-phase peptide synthesis allows for efficient coupling reactions, leading to high yields and purity of the final products. Researchers in medicinal chemistry and biochemistry can leverage this compound to explore novel therapeutic agents, particularly in the fields of oncology and infectious diseases, where fluorinated amino acids have shown promising results in enhancing drug efficacy.

Synonyms
Fmoc-L-Phe(4-Cl,2-F)-OH, (S)-Fmoc-2-amino-4-chloro-2-fluorophenylpropionic acid, Fmoc-Phe(4-Cl,2-F)-OH
CAS Number
1217811-90-9
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C24H19ClFNO4
Molecular Weight
439.86
MDL Number
MFCD12198170
PubChem ID
53398088
Appearance
White solid
Optical Rotation
[a]D20 = -40 ± 1 ° (C=1 in DMF)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
Fmoc-L-Phe(4-Cl,2-F)-OH, (S)-Fmoc-2-amino-4-chloro-2-fluorophenylpropionic acid, Fmoc-Phe(4-Cl,2-F)-OH
CAS Number
1217811-90-9
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C24H19ClFNO4
Molecular Weight
439.86
MDL Number
MFCD12198170
PubChem ID
53398088
Appearance
White solid
Optical Rotation
[a]D20 = -40 ± 1 ° (C=1 in DMF)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-4-chloro-2-fluoro-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a crucial building block in the synthesis of peptides, allowing researchers to create complex structures for studying protein interactions and functions.
  • Drug Development: Its unique properties make it valuable in medicinal chemistry, particularly in the design of novel therapeutics targeting specific diseases, such as cancer and bacterial infections.
  • Bioconjugation: The chemical is used in bioconjugation techniques, enabling the attachment of biomolecules to drugs or imaging agents, enhancing their efficacy and targeting capabilities.
  • Fluorescent Labeling: Researchers utilize this compound for fluorescent labeling in various assays, improving the detection and quantification of biomolecules in biological samples.
  • Research in Neurobiology: It plays a role in neurobiology studies, helping scientists investigate the effects of peptides on neuronal signaling and potential therapeutic applications in neurodegenerative diseases.

Citations