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Fmoc-2,4-difluoro-L-phenylalanine
Fmoc-2,4-difluoro-L-phenylalanine is widely utilized in research focused on:
- Peptide Synthesis: This compound serves as a crucial building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the incorporation of fluorinated amino acids which can enhance the stability and bioactivity of the resulting peptides.
- Drug Development: Its unique properties make it valuable in the design of pharmaceuticals, especially in creating compounds with improved pharmacokinetics and selectivity, which is essential in the development of targeted therapies.
- Bioconjugation: The presence of the Fmoc protecting group allows for selective reactions in bioconjugation processes, facilitating the attachment of peptides to various biomolecules, which is important in creating targeted drug delivery systems.
- Research in Protein Engineering: Researchers utilize this amino acid to study protein folding and stability, as the difluoro substitution can significantly influence the structural properties of proteins, leading to insights in protein design.
- Fluorine Chemistry Studies: The incorporation of fluorine into organic compounds is a growing field, and this amino acid serves as a model compound for studying the effects of fluorination on biological activity and chemical reactivity.
General Information
Properties
Safety and Regulations
Applications
Fmoc-2,4-difluoro-L-phenylalanine is widely utilized in research focused on:
- Peptide Synthesis: This compound serves as a crucial building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the incorporation of fluorinated amino acids which can enhance the stability and bioactivity of the resulting peptides.
- Drug Development: Its unique properties make it valuable in the design of pharmaceuticals, especially in creating compounds with improved pharmacokinetics and selectivity, which is essential in the development of targeted therapies.
- Bioconjugation: The presence of the Fmoc protecting group allows for selective reactions in bioconjugation processes, facilitating the attachment of peptides to various biomolecules, which is important in creating targeted drug delivery systems.
- Research in Protein Engineering: Researchers utilize this amino acid to study protein folding and stability, as the difluoro substitution can significantly influence the structural properties of proteins, leading to insights in protein design.
- Fluorine Chemistry Studies: The incorporation of fluorine into organic compounds is a growing field, and this amino acid serves as a model compound for studying the effects of fluorination on biological activity and chemical reactivity.
Documents
Safety Data Sheets (SDS)
The SDS provides comprehensive safety information on handling, storage, and disposal of the product.
Product Specification (PS)
The PS provides a comprehensive breakdown of the product’s properties, including chemical composition, physical state, purity, and storage requirements. It also details acceptable quality ranges and the product's intended applications.
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
*Catalog Number
*Lot Number
Certificates Of Origin (COO)
This COO confirms the country where the product was manufactured, and also details the materials and components used in it and whether it is derived from natural, synthetic, or other specific sources. This certificate may be required for customs, trade, and regulatory compliance.
*Catalog Number
*Lot Number
Safety Data Sheets (SDS)
The SDS provides comprehensive safety information on handling, storage, and disposal of the product.
DownloadProduct Specification (PS)
The PS provides a comprehensive breakdown of the product’s properties, including chemical composition, physical state, purity, and storage requirements. It also details acceptable quality ranges and the product's intended applications.
DownloadCertificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
*Catalog Number
*Lot Number
Certificates Of Origin (COO)
This COO confirms the country where the product was manufactured, and also details the materials and components used in it and whether it is derived from natural, synthetic, or other specific sources. This certificate may be required for customs, trade, and regulatory compliance.