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Catalog Number:
33590
CAS Number:
1217820-78-4
Fmoc-2,4-difluoro-D-phenylalanine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-D-Phe(2,4-DiF)-OH, Fmoc-(R)-2-amino-3-(2,4-difluorophenyl)propionic acid
Documents
$45.77 /100MG
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Product Information

Fmoc-2,4-difluoro-D-phenylalanine is a valuable amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique difluorophenyl group, which enhances its biochemical properties, making it an excellent choice for researchers focused on developing novel therapeutics. Its Fmoc (9-fluorenylmethoxycarbonyl) protecting group allows for easy incorporation into peptides while maintaining stability during synthesis. This characteristic is particularly beneficial in solid-phase peptide synthesis, where efficiency and yield are paramount.

In addition to its role in peptide synthesis, Fmoc-2,4-difluoro-D-phenylalanine has shown potential in the design of fluorinated compounds that can improve the pharmacokinetic profiles of drugs. The incorporation of fluorine atoms can enhance lipophilicity and metabolic stability, making this compound a strategic choice for medicinal chemists aiming to optimize drug candidates. Its unique properties and applications make it a sought-after reagent in both academic and industrial settings.

Synonyms
Fmoc-D-Phe(2,4-DiF)-OH, Fmoc-(R)-2-amino-3-(2,4-difluorophenyl)propionic acid
CAS Number
1217820-78-4
Purity
≥ 99% (HPLC)
Molecular Formula
C24H19F2NO4
Molecular Weight
423.41
MDL Number
MFCD07371997
PubChem ID
16244020
Melting Point
152 - 157 ?C
Appearance
White powder
Optical Rotation
[a]20D = 43 ± 2 ° (C = 1 in DMF)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
Fmoc-D-Phe(2,4-DiF)-OH, Fmoc-(R)-2-amino-3-(2,4-difluorophenyl)propionic acid
CAS Number
1217820-78-4
Purity
≥ 99% (HPLC)
Molecular Formula
C24H19F2NO4
Molecular Weight
423.41
MDL Number
MFCD07371997
PubChem ID
16244020
Melting Point
152 - 157 ?C
Appearance
White powder
Optical Rotation
[a]20D = 43 ± 2 ° (C = 1 in DMF)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-2,4-difluoro-D-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a crucial building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS). Its unique fluorine substitutions enhance the stability and bioactivity of the resulting peptides.
  • Drug Development: Researchers leverage its properties to design and optimize new pharmaceuticals, especially in the development of peptide-based drugs that target specific biological pathways.
  • Bioconjugation: The chemical is used in bioconjugation processes, allowing for the attachment of biomolecules to peptides. This application is vital in creating targeted drug delivery systems and diagnostic agents.
  • Fluorinated Compounds Research: Its fluorinated nature makes it an excellent candidate for studies exploring the effects of fluorination on biological activity, providing insights that can lead to the development of more effective therapeutic agents.
  • Analytical Chemistry: The compound is employed in analytical methods to study protein interactions and conformational changes, helping researchers understand complex biological systems better.

Citations