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Catalog Number:
33564
CAS Number:
1378847-51-8
Fmoc-(2R,4R-4-azidoproline
Purity:
≥ 99% (HPLC, Assay by titration)
Synonym(s):
Fmoc-Pro(4-N3) (2R,4R
Antibiotic
Documents
$134.70 /25MG
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Product Information

Fmoc-(2R,4R)-4-azidoproline is a versatile building block in peptide synthesis, particularly valued for its unique azido functional group, which allows for further modifications through click chemistry. This compound is particularly useful in the development of peptide-based therapeutics and bioconjugates, enabling researchers to create complex molecular architectures with high specificity. Its Fmoc (9-fluorenylmethoxycarbonyl) protecting group facilitates easy incorporation into peptide chains while maintaining stability during synthesis.

The azido group provides a reactive site for various coupling reactions, making Fmoc-(2R,4R)-4-azidoproline an essential tool in medicinal chemistry and materials science. Researchers can leverage its properties to explore innovative applications, such as drug delivery systems and the development of novel biomaterials. With its ability to enhance the functionality of peptides, this compound stands out as a valuable asset for professionals aiming to push the boundaries of peptide research and development.

Synonyms
Fmoc-Pro(4-N3) (2R,4R
CAS Number
1378847-51-8
Purity
≥ 99% (HPLC, Assay by titration)
Molecular Formula
C20H18N4O4
Molecular Weight
378.4
MDL Number
MFCD32069103
PubChem ID
21467060
Melting Point
177 - 180 ?C
Appearance
White crystalline powder
Optical Rotation
[a]20D = 15 ± 1 ° (C=1 in DMF)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
Fmoc-Pro(4-N3) (2R,4R
CAS Number
1378847-51-8
Purity
≥ 99% (HPLC, Assay by titration)
Molecular Formula
C20H18N4O4
Molecular Weight
378.4
MDL Number
MFCD32069103
PubChem ID
21467060
Melting Point
177 - 180 ?C
Appearance
White crystalline powder
Optical Rotation
[a]20D = 15 ± 1 ° (C=1 in DMF)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
Yes
DEA-regulated
No
Warnings
-
Applications

Fmoc-(2R,4R)-4-azidoproline is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in the development of novel therapeutic agents. Its azide group allows for click chemistry, facilitating efficient coupling reactions.
  • Drug Development: Researchers use it to create bioactive compounds that can target specific diseases. Its unique structure enhances the stability and efficacy of potential drug candidates.
  • Bioconjugation: The azide functionality enables bioconjugation techniques, allowing scientists to attach biomolecules to surfaces or other molecules, which is crucial in the development of targeted drug delivery systems.
  • Protein Engineering: It is employed in the modification of proteins to study their functions or to create proteins with enhanced properties, aiding in the development of diagnostic tools and therapeutic proteins.
  • Material Science: The compound is also explored in the creation of functional materials, such as hydrogels, which can be used in tissue engineering and regenerative medicine due to their biocompatibility and tunable properties.

Citations