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Catalog Number:
33497
CAS Number:
2137142-63-1
Fmoc-(4S)-4-azido-D-proline
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-Pro(4-N3)-OH (2R,4S), Fmoc-(2R,4S)-4-azidoproline
Antibiotic
Documents
$60.00 /25MG
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Product Information

Fmoc-(4S)-4-Azido-D-Proline is a versatile building block widely used in peptide synthesis and medicinal chemistry. This compound features a unique azido group that enhances its reactivity, making it an excellent candidate for click chemistry applications. Its Fmoc protecting group allows for easy incorporation into peptide sequences, facilitating the synthesis of complex peptides and proteins. Researchers appreciate its utility in the development of bioactive compounds, particularly in the fields of drug discovery and development, where it can be employed to create novel therapeutics with enhanced efficacy.

The compound's specific stereochemistry and functional groups enable selective modifications, allowing for the introduction of diverse functionalities into peptide chains. This makes Fmoc-(4S)-4-Azido-D-Proline particularly valuable for applications in targeted drug delivery and the design of peptide-based vaccines. Its ability to participate in various coupling reactions further expands its applicability in the synthesis of peptide libraries, providing researchers with a powerful tool for exploring structure-activity relationships in drug development.

Synonyms
Fmoc-D-Pro(4-N3)-OH (2R,4S), Fmoc-(2R,4S)-4-azidoproline
CAS Number
2137142-63-1
Purity
≥ 98% (HPLC)
Molecular Formula
C20H18N4O4
Molecular Weight
378.4
MDL Number
MFCD31380719
PubChem ID
21467060
Melting Point
140 - 144 ?C
Appearance
White crystalline powder
Optical Rotation
[a]20D = +35 ± 1 ° (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-D-Pro(4-N3)-OH (2R,4S), Fmoc-(2R,4S)-4-azidoproline
CAS Number
2137142-63-1
Purity
≥ 98% (HPLC)
Molecular Formula
C20H18N4O4
Molecular Weight
378.4
MDL Number
MFCD31380719
PubChem ID
21467060
Melting Point
140 - 144 ?C
Appearance
White crystalline powder
Optical Rotation
[a]20D = +35 ± 1 ° (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
Yes
DEA-regulated
No
Warnings
-
Applications

Fmoc-(4S)-4-Azido-D-Proline is widely utilized in research focused on:

  • Peptide Synthesis: This compound is commonly used in the synthesis of peptides, particularly in the development of new therapeutic agents. Its unique azido group allows for selective modifications, enhancing the versatility of peptide design.
  • Bioconjugation: The azido group facilitates click chemistry reactions, making it ideal for bioconjugation applications. This is particularly useful in drug delivery systems and the development of targeted therapies.
  • Protein Labeling: Researchers employ this compound for labeling proteins with fluorescent tags or other markers. This application is essential in studying protein interactions and dynamics in cellular environments.
  • Drug Development: Its role in the synthesis of novel compounds makes it valuable in pharmaceutical research, especially in creating molecules with improved efficacy and selectivity for specific biological targets.
  • Material Science: The compound is also explored in the field of material science for developing smart materials that respond to environmental stimuli, leveraging its unique chemical properties.

Citations